Comparison of Paraffin Oil Versus Lactulose in Children with Functional Constipation
DOI:
https://doi.org/10.70749/ijbr.v3i6.1660Keywords:
Functional Constipation, Paraffin Oil, Lactulose, PediatricAbstract
Background: Functional constipation is a common pediatric condition that significantly impacts quality of life. Various laxatives including paraffin oil and lactulose are used for treatment, but comparative efficacy in different demographic groups remains underexplored, especially in resource-limited settings. Objective: To compare the efficacy of paraffin oil and lactulose in children with functional constipation. Study Design: Randomized controlled trial. Duration and Place of Study: Conducted from February 2024 to August 2024 at the Department of Pediatrics, Lady Reading Hospital, Peshawar. Methodology: Sixty children with functional constipation were randomized into two groups of 30 each. Group A received oral paraffin oil, and Group B received oral lactulose, both administered twice daily for eight weeks. Treatment efficacy was assessed based on stool frequency and encopresis episodes recorded by parents during follow-ups at four and eight weeks. Results: Baseline demographics were comparable between groups. Overall efficacy was significantly higher in the paraffin oil group (83.3%) compared to the lactulose group (56.7%) (p=0.047). Stratified analysis revealed paraffin oil’s superior efficacy in younger children (≤6 years), females, and lower socioeconomic and educational backgrounds. Conclusion: Paraffin oil is more effective than lactulose for treating functional constipation in children, particularly in younger age groups and socioeconomically disadvantaged populations, making it a preferred treatment option in similar clinical settings.
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Rajindrajith, S., Devanarayana, N. M., & Benninga, M. A. (2022). Childhood constipation: Current status, challenges, and future perspectives. World Journal of Clinical Pediatrics, 11(5), 385-404.
https://doi.org/10.5409/wjcp.v11.i5.385
Tran, D. L., & Sintusek, P. (2023). Functional constipation in children: What physicians should know. World Journal of Gastroenterology, 29(8), 1261-1288.
https://doi.org/10.3748/wjg.v29.i8.1261
Koppen, I. J., & Benninga, M. A. (2022). Functional constipation and Dyssynergic defecation in children. Frontiers in Pediatrics, 10.
https://doi.org/10.3389/fped.2022.832877
Wallace, C., Sinopoulou, V., Gordon, M., Akobeng, A. K., Llanos-Chea, A., Hungria, G., Febo-Rodriguez, L., Fifi, A., Fernandez Valdes, L., Langshaw, A., & Saps, M. (2022). Probiotics for treatment of chronic constipation in children. Cochrane Database of Systematic Reviews, 2022(3).
https://doi.org/10.1002/14651858.cd014257.pub2
Lamanna, A., Dughetti, L. D., Jordan‐Ely, J. A., Dobson, K. M., Dynan, M., Foo, A., Kooiman, L. M., Murakami, N., Fiuza, K., Foroughi, S., Leal, M., Vidmar, S., Catto‐Smith, A. G., Hutson, J. M., & Southwell, B. R. (2018). Treatment of fecal impaction in children using combined polyethylene glycol and sodium picosulphate. JGH Open, 2(4), 144-151.
https://doi.org/10.1002/jgh3.12062
Claßen, M., Righini-Grunder, F., Schumann, S., Von Gontard, A., & De Laffolie, J. (2022). Constipation in children and adolescents. Deutsches Ärzteblatt international.
https://doi.org/10.3238/arztebl.m2022.0309
Bassotti, G., Usai Satta, P., & Bellini, M. (2021). Chronic idiopathic constipation in adults: A review on current guidelines and emerging treatment options. Clinical and Experimental Gastroenterology, 14, 413-428.
https://doi.org/10.2147/ceg.s256364
Cho, Y. S., Lee, Y. J., Shin, J. E., Jung, H., Park, S., Kang, S. J., Song, K. H., Kim, J., Lim, H. C., Park, H. S., Kim, S., Cha, R. R., Bang, K. B., Bang, C. S., Yim, S. K., Ryoo, S., Kye, B. H., Ji, W. B., & Choi, M. (2023). 2022 Seoul consensus on clinical practice guidelines for functional constipation. Journal of Neurogastroenterology and Motility, 29(3), 271-305.
https://doi.org/10.5056/jnm23066
De Geus, A., Koppen, I. J., Flint, R. B., Benninga, M. A., & Tabbers, M. M. (2023). An update of pharmacological management in children with functional constipation. Pediatric Drugs, 25(3), 343-358.
https://doi.org/10.1007/s40272-023-00563-0
Harris, R. G., Neale, E. P., & Batterham, M. (2024). Efficacy of probiotics compared with pharmacological treatments for maintenance therapy for functional constipation in children: A systematic review and network meta-analysis. Nutrition Reviews, 83(6), 1006-1034.
https://doi.org/10.1093/nutrit/nuae119
Sharif, F., Crushell, E., O'Driscoll, K., & Bourke, B. (2001). Liquid paraffin: A reappraisal of its role in the treatment of constipation. Archives of Disease in Childhood, 85(2), 121-124.
https://doi.org/10.1136/adc.85.2.121
Chu, N., Ling, J., Jie, H., Leung, K., & Poon, E. (2022). The potential role of lactulose pharmacotherapy in the treatment and prevention of diabetes. Frontiers in Endocrinology, 13.
https://doi.org/10.3389/fendo.2022.956203
Zhang, Y., Li, A., Qiu, J., Wen, H., Zhang, H., & Sun, X. (2024). Probiotics for functional constipation in children: An overview of overlapping systematic reviews. Frontiers in Cellular and Infection Microbiology, 13.
https://doi.org/10.3389/fcimb.2023.1323521
Karakan, T., Tuohy, K. M., & Janssen-van Solingen, G. (2021). Low-dose Lactulose as a prebiotic for improved gut health and enhanced mineral absorption. Frontiers in Nutrition, 8.
https://doi.org/10.3389/fnut.2021.672925
Farahmand, F. (2007). A randomised trial of liquid paraffin versus lactulose in the treatment of chronic functional constipation in children. Acta Med Iran, 45(3), 183-8.
Hassan, K., Hussein, K., Alireza, A., Mohammad, K., Ali, T., Parisan, N., & Hussein, S. (2008). Comparison the efficacy of polyethylene glycol and paraffin for the treatment of childhood functional constipation. Medwell Res J Biol Sci, 3(6), 665-8.
https://www.cabidigitallibrary.org/doi/full/10.5555/20083097867
Torabi, Z., Amiraslani, S., Diaz, D., Ahmadiafshar, A., & Eftekhari, K. (2017). Comparison of Paraffin versus Polyethylene Glycol (PEG) in Children with Chronic Functional Constipation. DOAJ (DOAJ: Directory of Open Access Journals), 5(10), 5845–5852.
https://doi.org/10.22038/ijp.2017.23726.2004
Parvin, A., Farzaneh, A., & Nasab Ali, H. (2012). A Comparative Trial: The Safety and Clinical Efficacy of PEG 3350 and Liquid Paraffin in Management of Chronic Functional Constipation in Children. International Journal of Clinical Medicine, 03(05), 383–386.
https://doi.org/10.4236/ijcm.2012.35072
Rowan-Legg, A. (2011). Managing functional constipation in children. Paediatrics & Child Health, 16(10), 661-665.
https://doi.org/10.1093/pch/16.10.661
Karami, H., Khademlou, M., & Niari, P. (2009). Polyethylene glycol versus paraffin for the treatment of childhood functional constipation. Iran J Pediatr, 19(3), 255-61.
Prasanth, K. (2022). Functional constipation in children. Annals of Pediatric Gastroenterology & Hepatology, 1(1), 1-9.
https://doi.org/10.5005/jp-journals-11009-0001
van der Spek N, (2019). Children with functional constipation. Health Service Executive.
Farahmand, F., Eftekhari, K., Modarresi, V., Najafi-Sani, M., Khodadad, A., & Motamed, F. (2010). Comparing oral route paraffin oil versus rectal route for disimpaction in children with chronic constipation; a randomized control trial. Iranian Journal of Pediatrics, 20(3), 291.
Farahmand, F. (2007). A randomised trial of liquid paraffin versus lactulose in the treatment of chronic functional constipation in children. Acta Med Iran, 45(3), 183-8.
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