Association of Thyroid Hormones with Aggression: A Neuroendocrine Approach
DOI:
https://doi.org/10.70749/ijbr.v3i6.1765Keywords:
Thyroid Hormones, Aggression, Neuroendocrinology, Hypothyroidism And Hyperthyroidism, HPA Axis, Emotional RegulationAbstract
Aggression, a hybrid behavior with biological, psychological, and social roots, is gradually associated with neuroendocrine mechanisms, particularly thyroid hormones. This review explains the complex association between thyroid hormones and aggressive behavior from clinical, neurodevelopmental, and neuroendocrine perspectives. Thyroid hormones, specifically triiodothyronine (T3) and thyroxine (T4), are critical in brain development, emotion regulation, and neurotransmitter intonation. Dysfunctions like hypothyroidism and hyperthyroidism are often associated with mood disturbances, irritability, impulsive behavior, and aggression. Moreover, the relationship between thyroid hormones and the hypothalamic-pituitary-adrenal (HPA) axis and their action on serotonergic, dopaminergic, and GABAergic systems makes them strong mediators for behavioral outcomes. Sex differences in thyroid dysregulation and aggression also specify the necessity for gender-specific research. Combining together clinical and experimental studies, this review highlights the aptitude of thyroid hormone profiling in risk assessment for aggression to the examination of thyroid-targeted treatments for the management of aggressive psychopathology.
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1. Acar, H., & Ulgen, A. (2020). Relationship between thyroid hormone levels and crime type: a controlled study in prisoners. International journal of endocrinology, 2020(1), 9172134.
https://doi.org/10.1155/2020/9172134
2. Ahmed, O. M., El-Gareib, A., El-Bakry, A., Abd El-Tawab, S., & Ahmed, R. (2008). Thyroid hormones states and brain development interactions. International journal of developmental neuroscience, 26(2), 147-209.
https://doi.org/10.1016/j.ijdevneu.2007.09.011
3. Aldhalemi, A. A., & Lahhob, Q. R. (2024). The study of chemical reactions in the human body through the use of hormones. International Journal of Advanced Biochemistry Research, 8(5), 01-09.
https://doi.org/10.33545/26174693.2024.v8.i5a.1048
4. Arianas, G. Κ., Kostopoulou, E., Ioannidis, A., Dimopoulos, I., Chiotis, C., Prezerakos, P., Spiliotis, B. E., & Rojas Gil, A. P. (2022). Emotional intelligence scores in children and adolescents with subclinical hypothyroidism—correlation with serum serotonin and thyroid-stimulating hormone (TSH) concentrations. Hormones, 1-8.
https://doi.org/10.1007/s42000-021-00320-3
5. Ausó, E., Lavado-Autric, R. a., Cuevas, E., Del Rey, F. E., Morreale de Escobar, G., & Berbel, P. (2004). A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology, 145(9), 4037-4047.
https://doi.org/10.1210/en.2004-0274
6. Baksi, S., & Pradhan, A. (2021). Thyroid hormone: sex-dependent role in nervous system regulation and disease. Biology of sex differences, 12(1), 25.
https://doi.org/10.1186/s13293-021-00367-2
7. Bernal, J. (2005). Thyroid hormones and brain development. Vitamins & Hormones, 71, 95-122.
https://doi.org/10.1016/s0083-6729(05)71004-9
8. Bhavani, S. S., & Abdelmalak, B. (2025). Anatomy of the Airway/Airway Management. Basic Sciences in Anesthesia, 67-102.
https://doi.org/10.1007/978-3-031-60203-0_4
9. Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M. (2019). Paradigms of dynamic control of thyroid hormone signaling. Endocrine reviews, 40(4), 1000-1047.
https://doi.org/10.1210/er.2018-00275
10. Brown, E. D., Obeng-Gyasi, B., Hall, J. E., & Shekhar, S. (2023). The thyroid hormone axis and female reproduction. International Journal of Molecular Sciences, 24(12), 9815.
https://doi.org/10.3390/ijms24129815
11. Buades-Rotger, M., Engelke, C., & Krämer, U. M. (2019). Trait and state patterns of basolateral amygdala connectivity at rest are related to endogenous testosterone and aggression in healthy young women. Brain imaging and behavior, 13, 564-576.
12. Chakrabarti, N., Sarkar, P. K., Ray, A. K., & Martin, J. V. (2023). Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman. Frontiers in Endocrinology, 14, 1240265.
https://doi.org/10.3389/fendo.2023.1240265
13. Chourasiya, S. (2024). THE ROLE OF OXIDATIVE STRESS IN HUMAN PATHOLOGY WITH A SPECIAL ATTENTION TO THYROID DISORDERS. Frontiers in Animal Science: Research and Development Volume I, 45.
14. Cocco, R., Arfuso, F., Giannetto, C., Piccione, G., Cesarani, A., Pulina, G., & Sechi, S. (2023). A preliminary study on the interplay between the serum levels of neurotransmitters and thyroid hormones for the evaluation of the behavioral phenotype of dogs. Animals, 13(3), 411.
15. de Escobar, G. M., Obregón, M. a. J., & del Rey, F. E. (2004). Maternal thyroid hormones early in pregnancy and fetal brain development. Best practice & research Clinical endocrinology & metabolism, 18(2), 225-248.
https://doi.org/10.1016/j.beem.2004.03.012
16. De Groot, L., Chrousos, G., & Dungan, K. (2015). Thyroid Hormones in Brain Development and Function. Endotext-NCBI Bookshelf, 2000, 1-62.
17. Dehesh, T., Mosleh-Shirazi, M. A., & Dehesh, P. (2025). Prevalence and associated factors of anxiety and depression among patients with hypothyroidism in Southern Iran. BMC psychiatry, 25(1), 54.
https://doi.org/10.1186/s12888-025-06490-3
18. Emir, B. S., Yıldız, S., Kılıçaslan, A. K., Kurt, O., & Gözel, N. (2022). The correlations between serum thyroid hormone levels, crime, impulsivity and aggression in high-security forensic psychiatry service patients. Turkish Journal of Health Science and Life, 5(3), 174-181.
19. Evrensel, A., Ünsalver, B. Ö., & Özşahin, A. (2016). The relationship between aggression and serum thyroid hormone level in individuals diagnosed with antisocial personality disorder. Nöro Psikiyatri Arşivi, 53(2), 120.
20. Fahlgren, M. K., Cheung, J. C., Ciesinski, N. K., McCloskey, M. S., & Coccaro, E. F. (2022). Gender differences in the relationship between anger and aggressive behavior. Journal of Interpersonal Violence, 37(13-14), NP12661-NP12670.
https://doi.org/10.1177/0886260521991870
21. Farooqi, S., Raj, S., Koyfman, A., & Long, B. (2023). High risk and low prevalence diseases: Thyroid storm. The American journal of emergency medicine, 69, 127-135.
22. Fekete, C., & Lechan, R. M. (2014). Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions. Endocrine reviews, 35(2), 159-194.
https://doi.org/10.1210/er.2013-1087
23. Franjić, S. Thyroid Hormones are Essential for Normal Life. Endocrinology and Dysfunctions, 1(1).
24. Gokcay, H., Balcioglu, Y. H., & Solmaz, M. (2022). The Role of Impulsive and Aggressive Traits, Albumin and Thyroid Functions in Recent Suicide Attempters: An Investigation with a Transdiagnostic Approach. Neurochemical Journal, 16(4), 491-497.
25. HAZAR, M., BEYLEROĞLU, M., YALÇIN, S., & ÇETİN, O. (2018). INVESTIGATION OF THE RELATIONSHIP BETWEEN ATHLETES AGGRESSIVE BEHAVIORS AND THYROID HORMONES. Ovidius University Annals, Series Physical Education & Sport/Science, Movement & Health, 18(1).
26. Henrichs, J., Bongers-Schokking, J. J., Schenk, J. J., Ghassabian, A., Schmidt, H. G., Visser, T. J., Hooijkaas, H., de Muinck Keizer-Schrama, S. M., Hofman, A., & Jaddoe, V. V. (2010). Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study. The Journal of Clinical Endocrinology & Metabolism, 95(9), 4227-4234.
https://doi.org/10.1210/jc.2010-0415
27. Herda, J., Okoński, P., Parfin, A., Wdowiak, K., & Kos, M. (2021). Thyroid diseases and mental illness together with behavioural disorders versus mental illness together with behavioural disorders and thyroid diseases. Polish Journal of Public Health, 131, 35-40.
28. Hong, H., & Lee, J. (2022). Thyroid-stimulating hormone as a biomarker for stress after thyroid surgery: a prospective cohort study. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 28, e937957-937951.
29. Hulbert, A. (2000). Thyroid hormones and their effects: a new perspective. Biological Reviews, 75(4), 519-631.
30. Jurado-Flores, M., Warda, F., & Mooradian, A. (2022). Pathophysiology and clinical features of neuropsychiatric manifestations of thyroid disease. Journal of the Endocrine Society, 6(2), bvab194.
https://doi.org/10.1210/jendso/bvab194
31. Kapri, D., Fanibunda, S. E., & Vaidya, V. A. (2022). Thyroid hormone regulation of adult hippocampal neurogenesis: Putative molecular and cellular mechanisms. In Vitamins and Hormones (Vol. 118, pp. 1-33). Elsevier.
32. Khan, A., Ullah, H., & Iftikhar, S. (2021). GENDER DIFFERENCES AND AGGRESSION: A COMPARATIVE STUDY OF YOUNG AND ADULT ATHLETES. Journal of Social Research Development, 02, 49-53. https://doi.org/10.53664/JSRD/02-01-2021-05-49-53
33. Kim, D., Liu, Q., Quartana, P. J., & Yoon, K. L. (2022). Gender differences in aggression: A multiplicative function of outward anger expression. Aggressive behavior, 48(4), 393-401.
34. Korevaar, T. I., Muetzel, R., Medici, M., Chaker, L., Jaddoe, V. W., de Rijke, Y. B., Steegers, E. A., Visser, T. J., White, T., & Tiemeier, H. (2016). Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study. The lancet Diabetes & endocrinology, 4(1), 35-43.
35. Kuś, A., Kjaergaard, A. D., Marouli, E., Del Greco M, F., Sterenborg, R. B., Chaker, L., Peeters, R. P., Bednarczuk, T., Åsvold, B. O., & Burgess, S. (2021). Thyroid function and mood disorders: a Mendelian randomization study. Thyroid, 31(8), 1171-1181.
https://doi.org/10.1089/thy.2020.0884
36. Maddox, S. A., Ponomareva, O. Y., Zaleski, C. E., Chen, M. X., Vella, K. R., Hollenberg, A. N., Klengel, C., & Ressler, K. J. (2025). Evidence for thyroid hormone regulation of amygdala-dependent fear-relevant memory and plasticity. Molecular Psychiatry, 30(1), 201-212.
37. Makadi, M., Ibrahim, I. A., Bahr, H. I., Elbaz, B. A., & Mahmoud, Y. K. (2024). The Biochemical and Behavioral Alterations Induced by Experimental Hyperthyroidism in Male Rats. Suez Canal Veterinary Medical Journal. SCVMJ.
38. Mbiydzenyuy, N. E., & Qulu, L.-A. (2024). Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression. Metabolic brain disease, 1-24.
https://doi.org/10.1007/s11011-024-01393-w
39. Munley, K. M., Rendon, N. M., & Demas, G. E. (2018). Neural androgen synthesis and aggression: insights from a seasonally breeding rodent. Frontiers in Endocrinology, 9, 136.
40. Narvaes, R., & Martins de Almeida, R. M. (2014). Aggressive behavior and three neurotransmitters: dopamine, GABA, and serotonin—A review of the last 10 years. Psychology & Neuroscience, 7(4), 601.
https://doi.org/10.3922/j.psns.2014.4.20
41. Nikolidaki, M. (2023). Hypothalamic–Pituitary-Thyroid (HPT) Axis and Affective Disorders. A Systematic Review European University of Cyprus (Cyprus)].
42. Nilsson, M., & Fagman, H. (2017). Development of the thyroid gland. Development, 144(12), 2123-2140.
43. Omon, E. A., & Ajay, O. D. (2023). Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction. European Journal of Clinical and Experimental Medicine(4), 768-775.
44. Osuna, E., Baumgartner, J., Walther, A., Emery, S., Albermann, M., Baumgartner, N., Schmeck, K., Walitza, S., Strumberger, M., & Hersberger, M. (2024). Investigating thyroid function and iodine status in adolescents with and without paediatric major depressive disorder. British Journal of Nutrition, 132(6), 725-737.
https://doi.org/10.1017/s0007114524001910
45. Ovčariček, P. P., Görges, R., & Giovanella, L. (2024). Autoimmune thyroid diseases. Seminars in nuclear medicine,
46. Pagnin, M., Kondos-Devcic, D., Chincarini, G., Cumberland, A., Richardson, S. J., & Tolcos, M. (2021). Role of thyroid hormones in normal and abnormal central nervous system myelination in humans and rodents. Frontiers in neuroendocrinology, 61, 100901.
47. Pankowski, D., Wytrychiewicz-Pankowska, K., Janowski, K., Pisula, E., & Fal, A. (2022). General and Illness-Specific Predictors of Adaptation to Chronic Illnesses: Cognitive Appraisals and Illness-related Beliefs. Advances in Cognitive Psychology, 18(2).
48. Pankowski, D., Wytrychiewicz-Pankowska, K., Janowski, K., Pisula, E., & Walicka, M. (2021). The role of illness-related beliefs in depressive, anxiety, and anger symptoms: an on-line survey in women with hypothyroidism. Frontiers in Psychiatry, 12, 614361.
https://doi.org/10.3389/fpsyt.2021.614361
49. Paul, S. N., Wingenfeld, K., Otte, C., & Meijer, O. C. (2022). Brain mineralocorticoid receptor in health and disease: From molecular signalling to cognitive and emotional function. British journal of pharmacology, 179(13), 3205-3219.
50. Popova, L., Vasylyeva, I., Nakonechnaya, O., & Vashchuk, M. (2018). Thyroid hormones role in neuroticism formation and aggression development.
51. Raji, H., Dinesh, S., & Sharma, S. (2025). Inside the impulsive brain: a narrative review on the role of neurobiological, hormonal and genetic factors influencing impulsivity in psychiatric disorders. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 61(1), 4.
52. Rawat, R. S., Bhambri, A., Pal, M., Roy, A., Jain, S., Pillai, B., & Konar, A. (2021). Early life trauma leads to escalated aggressive behavior and its inheritance by impairing thyroid hormone availability in brain. bioRxiv, 2021.2007. 2005.448713.
https://doi.org/10.7554/elife.77968
53. Rigó, A. HASHIMOTO'S THYROIDITIS IN HEALTH PSYCHOLOGICAL APPROACH. CLINICAL HEALTH PSYCHOLOGY IN PRACTICE, 59.
54. Rovet, J. F. (2014). The role of thyroid hormones for brain development and cognitive function. Endocr Dev, 26(26), 26-43.
55. Salas-Lucia, F. (2024). Mapping thyroid hormone action in the human brain. Thyroid, 34(7), 815-826.
56. Samuels, M. H. (2014). Psychiatric and cognitive manifestations of hypothyroidism. Current Opinion in Endocrinology, Diabetes and Obesity, 21(5), 377-383.
57. Sebastian, S. (2017). A Comparative Study on Physiological Taste Threshold in Hypo and Hyperthyroidism Rajiv Gandhi University of Health Sciences (India)].
58. Shaban, N., & Kumar, P. (2016). Young Adults and Aggression: A Comparative Study of Gender Differences. The International Journal of Indian Psychology, 3, 106-114.
https://doi.org/10.25215/0304.031
59. Shahid, M. A., Ashraf, M. A., & Sharma, S. (2018). Physiology, thyroid hormone.
60. Shorey, S., Ng, E. D., & Wong, C. H. (2022). Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta‐analysis. British Journal of Clinical Psychology, 61(2), 287-305.
61. Siegel, A., Bhatt, S., Bhatt, R., & Zalcman, S. S. (2007). The neurobiological bases for development of pharmacological treatments of aggressive disorders. Current neuropharmacology, 5(2), 135-147.
https://doi.org/10.2174/157015907780866929
62. Singh, B., & Sundaresh, V. (2022). Thyroid hormone use in mood disorders: revisiting the evidence. The Journal of Clinical Psychiatry, 83(5), 42331.
63. Singh, S., Kumar, M., Modi, S., Kaur, P., Shankar, L., & Khushu, S. (2015). Alterations of functional connectivity among resting‐state networks in hypothyroidism. Journal of neuroendocrinology, 27(7), 609-615.
64. Smith, S. M., & Vale, W. W. (2006). The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues in clinical neuroscience, 8(4), 383-395.
65. Soheili-Nezhad, S., Sprooten, E., Tendolkar, I., & Medici, M. (2023). Exploring the genetic link between thyroid dysfunction and common psychiatric disorders: a specific hormonal or a general autoimmune comorbidity. Thyroid, 33(2), 159-168.
https://doi.org/10.1089/thy.2022.0304
66. Song, X., Yan, S., Lai, S., Zhang, Y., Wang, Y., He, J., Huang, D., Zhang, J., Lu, X., & Chen, G. (2024). Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder. BMC psychiatry, 24(1), 949.
67. Stohn, J. P., Martinez, M. E., Zafer, M., López‐Espíndola, D., Keyes, L. M., & Hernandez, A. (2018). Increased aggression and lack of maternal behavior in Dio3‐deficient mice are associated with abnormalities in oxytocin and vasopressin systems. Genes, Brain and Behavior, 17(1), 23-35.
68. Sturmey, P. (2022). Biological evolution of violence and aggression. II: Brains, neurotransmitters, and hormones. In Violence and Aggression: Integrating Theory, Research, and Practice (pp. 121-143). Springer.
https://doi.org/10.1007/978-3-031-04386-4_5
69. Suteau, V., Munier, M., Briet, C., & Rodien, P. (2021). Sex bias in differentiated thyroid cancer. International Journal of Molecular Sciences, 22(23), 12992.
70. Święchowicz, B., Kasielska-Trojan, A., Manning, J. T., & Antoszewski, B. (2022). Can digit ratio (2D: 4D) be indicative of predispositions to autoimmune thyroid diseases in women-Hashimoto thyroiditis and Graves’ disease? Frontiers in Endocrinology, 13, 914471.
71. Terburg, D., Scheggia, D., Del Rio, R. T., Klumpers, F., Ciobanu, A. C., Morgan, B., Montoya, E. R., Bos, P. A., Giobellina, G., & van den Burg, E. H. (2018). The basolateral amygdala is essential for rapid escape: a human and rodent study. Cell, 175(3), 723-735. e716.
https://doi.org/10.1016/j.cell.2018.09.028
72. Torabinejad, S., Miro, C., Barone, B., Imbimbo, C., Crocetto, F., & Dentice, M. (2023). The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications. European thyroid journal, 12(3).
73. Trauner, D. A. (2024). Cognitive and Behavioral. Pediatric Behavioral Neurology, 251.
https://doi.org/10.1201/9781003574088-10
74. Trifu, S. C., Tudor, A., & Radulescu, I. (2020). Aggressive behavior in psychiatric patients in relation to hormonal imbalance. Experimental and therapeutic medicine, 20(4), 3483-3487.
https://doi.org/10.3892/etm.2020.8974
75. Vargas-Uricoechea, H., Castellanos-Pinedo, A., Urrego-Noguera, K., Pinzón-Fernández, M. V., Meza-Cabrera, I. A., & Vargas-Sierra, H. (2025). A Scoping Review on the Prevalence of Hashimoto’s Thyroiditis and the Possible Associated Factors. Medical Sciences, 13(2), 43.
https://doi.org/10.3390/medsci13020043
76. Wirth, M. M., Gaffey, A. E., & Work, H. (2013). Hormones and emotion. Handbook of cognition and emotion, 69.
77. Yılmazer, E. (2024). Hormonal Underpinnings of Emotional Regulation: Bridging Endocrinology and Psychology. The Journal of Neurobehavioral Sciences, 11(2), 60-75.
https://doi.org/10.32739/uha.jnbs.11.1539123
78. Yuan, H., Zhao, J., Xie, E., Yi, L., Zheng, Z., Geng, J., Yuan, H., Zhao, J., Xie, E., & Yi, L. (2021). Endocrine and Metabolic Diseases. In Clinical Molecular Diagnostics (pp. 665-716). Springer.
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