Different Clinical Presentations of Celiac Disease in Children

Authors

  • Iqra Naheed Department of Pediatrics, DHQ Hospital, Faisalabad, Punjab, Pakistan.
  • Rashid Nawaz Department of Pediatrics, DHQ Hospital, Faisalabad, Punjab, Pakistan.
  • Hina Umbreen Department of Pediatrics, DHQ Hospital, Faisalabad, Punjab, Pakistan
  • Uzma Yasmeen Department of Pediatrics, DHQ Hospital, Faisalabad, Punjab, Pakistan

DOI:

https://doi.org/10.70749/ijbr.v1i2.1828

Keywords:

Celiac Disease, Clinical Presentation, Gastrointestinal Symptoms.

Abstract

Objective: To determine the frequency of different clinical presentations in children having celiac disease. Study design: Cross sectional validation study. Settings: Department of Pediatrics, DHQ Hospital, Faisalabad. Study duration: April 21, 2024 to October 20, 2024. Materials and Procedures: This study included both male and female patients with celiac disease whose ages ranged from 1 to 14 years: Exclusion criteria were giardiasis, immunodeficiency, growth hormone deficit, IBD, abdominal TB, infective gastroenteritis, cystic fibrosis, primary malnutrition, and chronic kidney disease. The pathologist reported that a blood sample was sent to the hospital's pathology laboratory to estimate the ferritin level. With a dermatologist's opinion, dermatitis herpartiformis was evaluated. The patient or parent was asked about their stool history. The following conditions were evaluated: failure to thrive, dermatitis herpetiformis, iron deficiency anemia, and chronic diarrhea. Results: Following clinical presentations were common among children with celiac disease: iron deficiency anemia in 39 (43.33%), failure to thrive in 29 (32.22%), dermatitis herpetiformis in 22 (24.44%), short stature in 24 (26.67%), and chronic diarrhea in 43 (47.78%) patients. Conclusion: In this study, diarrhea, iron deficiency anemia, and failure to thrive were the most prevalent symptoms that children with celiac disease presented with.

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References

1. Imran, Cheema, H. A., Alvi, M. A., Rehman, M. U., Ali, M., & Sarwar, H. A. (2021). Spectrum of clinical presentation of celiac disease in pediatric population. Cureus, 13(6). https://doi.org/10.7759/cureus.15582

2. Rasheed, J., Khan, T., Khalid, M., & Zafar, F. (2018). Celiac disease; a medley of clinical features a tertiary care hospital experience. The Professional Medical Journal, 25(05), 669-675. https://doi.org/10.29309/tpmj/2018.25.05.306

3. Siddiqui, K., Rafiq, M., Bhutto, M. A., & Uqaili, A. A. (2021). Red Blood Indices, Platelet Count and Transferrin Levels in Celiac Patients with and Without Type 1 Diabetes Mellitus in Hyderabad, Sindh, Pakistan. Khyber Medical University Journal, 13(1). https://doi.org/10.35845/kmuj.2021.20553

4. Nardecchia, S., Auricchio, R., Discepolo, V., & Troncone, R. (2019). Extra-intestinal manifestations of coeliac disease in children: Clinical features and mechanisms. Frontiers in Pediatrics, 7. https://doi.org/10.3389/fped.2019.00056

5. Rubin, J. E., & Crowe, S. E. (2020). Celiac disease. Annals of Internal Medicine, 172(1), ITC1-ITC16. https://doi.org/10.7326/aitc202001070

6. Therrien, A., Kelly, C. P., & Silvester, J. A. (2019). Celiac disease: extraintestinal manifestations and associated conditions. Journal of Clinical Gastroenterology, 54(1), 8-21. https://doi.org/10.1097/mcg.0000000000001267

7. Javed, F., Sattar, F., Gill, A. A., Lodhi, Y., Iqbal, K., & Nazir, A. (2019). Clinical Spectrum of Celiac Disease in Children: Experience from A Public Hospital in Pakistan. Annals of Punjab Medical College (APMC), 13(3), 192–196. https://doi.org/10.29054/apmc/2019.145

8. Nurminen, S., Kivelä, L., Huhtala, H., Kaukinen, K., & Kurppa, K. (2018). Extraintestinal manifestations were common in children with coeliac disease and were more prevalent in patients with more severe clinical and histological presentation. Acta Paediatrica, 108(4), 681-687. https://doi.org/10.1111/apa.14324

9. Lionetti, E., Pjetraj, D., Gatti, S., Catassi, G., Bellantoni, A., Boffardi, M., Cananzi, M., Cinquetti, M., Francavilla, R., Malamisura, B., Montuori, M., Zuccotti, G., Cristofori, F., Gaio, P., Passaro, T., Penagini, F., Testa, A., Trovato, C. M., & Catassi, C. (2023). Prevalence and detection rate of celiac disease in Italy: Results of a SIGENP multicenter screening in school-age children. Digestive and Liver Disease, 55(5), 608-613. https://doi.org/10.1016/j.dld.2022.12.023

10. Catassi, C., Verdu, E. F., Bai, J. C., & Lionetti, E. (2022). Coeliac disease. The Lancet, 399(10344), 2413-2426. https://doi.org/10.1016/s0140-6736(22)00794-2

11. Bolia, R., & Thapar, N. (2023). Celiac disease in children: A 2023 update. Indian Journal of Pediatrics, 91(5), 481-489. https://doi.org/10.1007/s12098-023-04659-w

12. Trovato, C. M., Montuori, M., Oliva, S., Cucchiara, S., Cignarelli, A., & Sansone, A. (2020). Assessment of public perceptions and concerns of celiac disease: A Twitter-based sentiment analysis study. Digestive and Liver Disease, 52(4), 464-466. https://doi.org/10.1016/j.dld.2020.02.004

13. Di Biase, A. R., Marasco, G., Ravaioli, F., Colecchia, L., Dajti, E., Lecis, M., Passini, E., Alemanni, L. V., Festi, D., Iughetti, L., & Colecchia, A. (2021). Clinical presentation of celiac disease and diagnosis accuracy in a single-center European pediatric cohort over 10 years. Nutrients, 13(11), 4131. https://doi.org/10.3390/nu13114131

14. Mouslih, A., El Rhazi, K., Bahra, N., Lakhdar Idrissi, M., & Hida, M. (2023). Celiac disease in moroccan children: Diagnostic characteristics and determinants of diagnosis delay. Cureus. https://doi.org/10.7759/cureus.50800

15. Khatib, M., Baker, R. D., Ly, E. K., Kozielski, R., & Baker, S. S. (2016). Presenting pattern of pediatric celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 62(1), 60-63. https://doi.org/10.1097/mpg.0000000000000887

16. Krueger, A., Fahey, L., Sun, Q., Regis, S., Khavari, N., Jericho, H., Badalyan, V., Absah, I., Verma, R., Leonard, M. M., Weisbrod, V., Hajjat, T., Lee, D., Shull, M., Silvester, J. A., & Mallon, D. (2024). Clinical presentation and factors associated with gluten exposure in children with celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 79(4), 895-904. https://doi.org/10.1002/jpn3.12321

17. Roma, E., Panayiotou, J., Karantana, H., Constantinidou, C., Siakavellas, S. I., Krini, M., Syriopoulou, V. P., & Bamias, G. (2009). Changing pattern in the clinical presentation of pediatric celiac disease: A 30-Year study. Digestion, 80(3), 185-191. https://doi.org/10.1159/000227275

18. Pedretti, M., Sbravati, F., Allegri, D., Labriola, F., Lombardo, V., Spisni, E., Zarbo, C., & Alvisi, P. (2021). Is the clinical pattern of pediatric celiac disease changing? A thirty-years real-life experience of an Italian center. Italian Journal of Pediatrics, 47(1). https://doi.org/10.1186/s13052-021-01183-5

19. The work of WHO in the Eastern Mediterranean Region-Annual report of the regional director 2019.

20. Aggarwal, N., Dwarakanathan, V., Singh, A., Agarwal, A., Khuttan, A., Ahmed, A., Rajput, M. S., Chauhan, A., Banyal, V., Verma, A. K., Gupta, V., Lodha, R., Ahuja, V., & Makharia, G. K. (2021). Spectrum of height in patients with celiac disease. Indian Journal of Gastroenterology, 40(6), 604-612. https://doi.org/10.1007/s12664-021-01173-9

21. Jabeen, S., Khan, A. U., Ahmed, W., Ahmad, M., Jafri, S. A., Bacha, U., Ali, A., Muzammil, H. S., Alsagaby, S. A., Al Abdulmonem, W., Abdelgawad, M. A., Riaz, M., Mahwish, Nasir, M., Zafar, A., Tufail, T., Imran, M., Anwar Faridi, T., Aslam, M., … Ur-Rehman, H. (2022). Disease specific symptoms indices in patients with celiac disease—A hardly recognised entity. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.944449

22. Saadah, O. I. (2021). The impact of a gluten-free diet on the growth pattern of Saudi children with celiac disease. Journal of the Pakistan Medical Association, 1-17. https://doi.org/10.47391/jpma.1308

23. Talarico, V., Giancotti, L., Mazza, G. A., Miniero, R., & Bertini, M. (2021). Iron deficiency anemia in celiac disease. Nutrients, 13(5), 1695. https://doi.org/10.3390/nu13051695

24. Lu, C., Zhou, W., He, X., Zhou, X., & Yu, C. (2020). Vitamin D status and vitamin D receptor genotypes in celiac disease: A meta-analysis. Critical Reviews in Food Science and Nutrition, 61(12), 2098-2106. https://doi.org/10.1080/10408398.2020.1772716

25. Xin, C., Imanifard, R., Jarahzadeh, M., Rohani, P., Velu, P., & Sohouli, M. H. (2023). Impact of gluten-free diet on anthropometric indicators in individuals with and without celiac disease: A systematic review and meta-analysis. Clinical Therapeutics, 45(12), e243-e251. https://doi.org/10.1016/j.clinthera.2023.09.018.

26. Sansotta, N., Guandalini, S., Romano, S., Amirikian, K., Cipolli, M., Tridello, G., Barzaghi, S., & Jericho, H. (2020). The gluten free diet’s impact on growth in children with celiac disease in two different countries. Nutrients, 12(6), 1547. https://doi.org/10.3390/nu12061547

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Published

2025-02-28

How to Cite

Different Clinical Presentations of Celiac Disease in Children. (2025). Indus Journal of Bioscience Research, 3(2), 750-755. https://doi.org/10.70749/ijbr.v1i2.1828