Diagnostic Accuracy of Color Doppler Ultrasound in Detecting Portal Vein Thrombosis in Patients Having Hepatocellular Carcinoma Due to Chronic Hepatitis C Keep Triphasic CT as Gold Standard
DOI:
https://doi.org/10.70749/ijbr.v3i6.1917Keywords:
Portal Vein Thrombosis, Color Doppler, SensitivityAbstract
Objective: With triphasic CT as the gold standard, the purpose of this study is to ascertain the diagnostic accuracy of color doppler ultrasonography in identifying portal vein thrombosis in patients with hepatocellular carcinoma caused by chronic hepatitis C. Study design: Cross-sectional (validation) study. Settings: Department of Radiology, Fouji Foundation Hospital, Rawalpindi. Duration of study: September 2024 to February 2025. Methodology: The study comprised 334 patients, aged 18 to 60 years presenting with hepatocellular carcinoma due to chronic hepatitis C infection. Prothrombotic disorders such as protein C, S, or factor V deficiency were excluded. 3.5 MHz matched imaging and Doppler frequency transducer was used for Color Doppler US. GE and Philips Health Care's MDCT scanner 16 detectors were used to perform triphasic CT scans of the abdomen and pelvis. Consultant radiologists performed the color doppler and CT reports. Results: 92.12% color doppler sensitivity, 91.60% specificity, 94.44% PPV, 88.24% NPV, and 91.92% diagnostic accuracy were used to diagnose PVT. Conclusion: Doppler ultrasonography has been shown to have a good diagnostic accuracy in identifying portal vein thrombosis (PVT) in individuals with hepatocellular cancer.
Downloads
References
1. Khan, M. R., Samad, M., Khan, M. R., Anjum, H., Nawab, K., & Wahid, G. (2021). Diagnostic accuracy of triple phase computed tomography in detecting hepatocellular carcinoma keeping histopathology as gold standard. Khyber Journal Of Medical Sciences, 13(3), 389-392.
https://doi.org/10.70520/kjms.v13i3.166
2. Mansoor, A., Shaukat, R., Chaudhary, A., & Jehan, G. (2019). Diagnostic accuracy of Doppler ultrasonography in predicting presence of Esophageal varices in patients with Hepatitis-C induced cirrhosis. Journal of the College of Physicians and Surgeons Pakistan, 29(07), 612-615.
https://doi.org/10.29271/jcpsp.2019.07.612
3. Arif, Q. U., Jabeen, C., Siddiqui, U., Irshad, T. M., Khan, M. B., & Tahir, S. (2021). Diagnostic accuracy of ultrasound in detecting hepatocellular carcinoma keeping histopathology as gold standard. Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University, 17(2), 168-173.
https://doi.org/10.48036/apims.v17i2.368
4. Shi, B., Bian, C., Li, Z., Chen, J., Yang, D., Li, Y., Hao, X., & Ping, Y. (2023). Imaging findings of hepatocellular carcinoma with Portal vein tumor thrombosis secondary to hepatic Portal vein collateral circulation: A cross-sectional study. Journal of Gastrointestinal Oncology, 14(1), 334-351.
https://doi.org/10.21037/jgo-23-45
5. Gawande, R., Jalaeian, H., Niendorf, E., Olgun, D., Krystosek, L., Rubin, N., & Spilseth, B. (2019). MRI in differentiating malignant versus benign Portal vein thrombosis in patients with hepatocellular carcinoma: Value of post contrast imaging with subtraction. European Journal of Radiology, 118, 88-95.
https://doi.org/10.1016/j.ejrad.2019.07.008
6. Abdelsalam, E., Abdelraof, M., Hassan, M., & Ali, K. (2020). Role of color Doppler ultrasonography versus triphasic CT with portography in Portal vein thrombosis. Ain Shams Medical Journal, 71(4), 891-900.
https://doi.org/10.21608/asmj.2020.148939
7. Zhang, Y., Wu, J., & Li, L. (2022). Efficacy comparison of optimal treatments for hepatocellular carcinoma patients with Portal vein tumor thrombus. Annals of Hepatology, 27(1), 100552.
https://doi.org/10.1016/j.aohep.2021.100552
8. Sturm, L., Bettinger, D., Klinger, C., Krauss, T., Engel, H., Huber, J. P., Schmidt, A., Caca, K., Thimme, R., & Schultheiss, M. (2021). Validation of color Doppler ultrasound and computed tomography in the radiologic assessment of non-malignant acute splanchnic vein thrombosis. PLOS ONE, 16(12), e0261499.
https://doi.org/10.1371/journal.pone.0261499
9. Giri, S., Vaidya, A., Agrawal, D., Varghese, J., Patel, R. K., Tripathy, T., Singh, A., & Das, S. (2023). Role of contrast‐enhanced ultrasound for differentiation of benign vs. malignant Portal vein thrombosis in hepatocellular carcinoma – A systematic review a meta‐analysis. Australasian Journal of Ultrasound in Medicine, 27(1), 56-64.
https://doi.org/10.1002/ajum.12375
10. Samad, M., Shah, R., Khan, M. R., Afsar, M., Wahid, G., & Tankeen, N. (2022). Diagnostic accuracy of Doppler ultrasound in detection of Portal vein thrombosis in hepatocellular carcinoma. Khyber Journal of Medical Sciences, 15(1), 43-48.
https://doi.org/10.70520/kjms.v15i1.349
11. Gerges, A. M., Maaty, M. A., Fawzi, M. M., Hassan, A. H., Badr, A. S., & Madkour, S. S. (2024). Role of Doppler ultrasound and Triphasic CT in differentiation between benign and malignant Portal vein thrombosis. Journal of Medicine in Scientific Research, 7(3).
https://doi.org/10.59299/2537-0928.1078
12. Tarantino, L. (2015). Contrast-enhanced ultrasound in differentiating malignant from benign Portal vein thrombosis in hepatocellular carcinoma. World Journal of Gastroenterology, 21(32), 9457.
https://doi.org/10.3748/wjg.v21.i32.9457
13. Chartampilas, E., Rafailidis, V., Georgopoulou, V., Kalarakis, G., Hatzidakis, A., & Prassopoulos, P. (2022). Current imaging diagnosis of hepatocellular carcinoma. Cancers, 14(16), 3997.
https://doi.org/10.3390/cancers14163997
14. Sofia, C., Cattafi, A., Silipigni, S., Pitrone, P., Carerj, M., Marino, M., Pitrone, A., & Ascenti, G. (2021). Portal vein thrombosis in patients with chronic liver diseases: From conventional to quantitative imaging. European Journal of Radiology, 142, 109859.
https://doi.org/10.1016/j.ejrad.2021.109859
15. Khan, A. R., Wei, X., & Xu, X. (2021). Portal vein tumor thrombosis and hepatocellular carcinoma – The changing tides. Journal of Hepatocellular Carcinoma, 8, 1089-1115.
https://doi.org/10.2147/jhc.s318070
16. Luntsi, G., Muhammad, M. A., Shirama, Y. B., Lawal Mohammed, M., Suleiman, A., & Ochie, K. (2020). Sonographic evaluation of the Portal vein diameter in patients with chronic liver disease in northeastern Nigeria. Ultrasound, 29(1), 36-43.
https://doi.org/10.1177/1742271x20944981
17. Serag, W. M., & Eysa, B. E. (2022). Diagnosis of Portal vein thrombosis in cirrhotic patients with and without hepatocellular carcinoma. Egyptian Liver Journal, 12(1).
https://doi.org/10.1186/s43066-022-00201-3
18. Shakeel, L., & Perveen, R. (2025). Doppler ultrasound evaluation of Portal vein thrombosis in cirrhotic patients with and without hepatocellular carcinoma. Journal of Biological and Allied Health Sciences, 5(1), 103-109.
https://doi.org/10.56536/jbahs.v5i1.121
19. Imtiaz, M., Awan, N., Butt, E. H., Najam, Z., Noor, S., & Mushtaq, W. (2023). Diagnostic accuracy of Doppler ultrasound in detection of Portal vein thrombosis in patient with hepatocellular carcinoma taking computed tomography (CT) as a gold standard. Pakistan Journal of Medical & Health Sciences, 17(12), 317-319.
https://doi.org/10.53350/pjmhs020231712317
20. Prakash, S., Bies, J., Hassan, M., Mares, A., & Didia, S. C. (2023). Portal vein thrombosis in cirrhosis: A literature review. Frontiers in Medicine, 10.
https://doi.org/10.3389/fmed.2023.1134801
21. Khan, F. Y., Habas, E., Sulaiman, T. O., Hamid, O. A., Abdalhadi, A., Khalaf, A., Afana, M. S., Ali, M. Y., Baniamer, Y. Z., Kanjo, W., Muthanna, B., & Akbar, R. A. (2022). Risk Factors, Clinical Presentation, Diagnosis, and Treatment Outcomes of Portal Vein Thrombosis: A Five-Year Hospital-Based Study From Qatar. Journal of Clinical Medicine Research, 14(5), 209–217.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
