Comparison of the Efficacy of Caffeine with Aminophylline for Management of Infants having Apnea of Prematurity

Hina Umbreen; Aamir Nasir Qureshi; Saim Shahid; Iqra Naheed; Hafiz Muhammad Abdullah

doi:10.70749/ijbr.v3i2.1918

Authors

Hina Umbreen Pediatrics Unit 2, Allied Hospital, Faisalabad, Punjab, Pakistan.
Aamir Nasir Qureshi Pediatrics Unit 2, Allied Hospital, Faisalabad, Punjab, Pakistan.
Saim Shahid Pediatrics Unit 2, Allied Hospital, Faisalabad, Punjab, Pakistan.
Iqra Naheed Pediatrics Unit 2, Allied Hospital, Faisalabad, Punjab, Pakistan.
Hafiz Muhammad Abdullah Pediatrics Unit 2, Allied Hospital, Faisalabad, Punjab, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i2.1918

Keywords:

Apnea of Prematurity, Caffeine, Aminophylline

Abstract

Objective: To compare the efficacy of caffeine with aminophylline for management of infants having apnea of prematurity. Study design: Randomized Controlled Trials. Settings: Department of Pediatrics, Allied Hospital, Faisalabad. Study duration: April 2024 to September 2024. Materials & Methods: A total of 140 patients (70 in each group), both male and female infants with birth weights greater than 500 g and gestational ages between 23 and 35 weeks who had multiple episodes of preterm apnea over the course of a 24-hour period were included. Neuromuscular abnormalities, prenatal asphyxia, cerebral hemorrhage, metabolic disorders, anemia, disseminated infections, congenital illnesses, and neonates whose mothers took painkillers were not included. Using a computer-generated random number table, the patients were split into two equal groups at random. A group of seventy patients had 30 mg/kg of caffeine mixed with 5% dextrose. They also got an intravenous maintenance dose of 10 mg/kg every 24 hours. Within three days of beginning treatment, bradycardia, hypoxia, and breathing were recorded, and the treatment's effectiveness was evaluated. Results: The average age of patients in group A was 10.69 ± 5.01 hours, whereas the average age of patients in group B was 11.84 ± 4.91 hours. There were 73 (52.14%) females and 67 (47.86%) males. The mean gestational age in groups A and B was 32.92 ± 1.55 weeks and 31.84 ± 1.42 weeks, respectively. The average blood sugar level was 82.34 ± 9.42 mg/dl. Weight at birth was 1234.54 ± 234.72 grams on average. At one minute and five minutes, the mean Apgar score was 7.72 ± 1.43 and 8.13 ± 0.89, respectively. 45 patients (64.29%) in group B (aminophylline) and 62 patients (85.71%) in group A (caffeine) showed efficacy. The statistically significant p-value is 0.003. Conclusion: According to the study's findings, caffeine is a safer and more effective treatment for preterm apnea than aminophylline.

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