Cervical Smear Abnormalities and Associated Risk Factors in Women Focus on HPV Status
DOI:
https://doi.org/10.70749/ijbr.v3i2.1951Keywords:
Cervical Cancer, Cervical Smear, Pap Smear, Human Papillomavirus, Oral ContraceptionAbstract
This study aimed to investigate the prevalence of cervical smear abnormalities among 63 women, aged 30 to 60 years, and to identify potential risk factors. The overall prevalence of abnormal cervical smears was 29.8%, with no significant age-related variation across the three age groups: 30–40 years (27.5%), 40–50 years (26.8%), and 50–60 years (33.8%) (p=0.608). Parity was not associated with cervical smear abnormalities, as the prevalence was similar in women with 1–3 births (30.3%) and those with 4–6 births (28.6%) (p=0.812). A significant association was observed between partner HPV status and abnormal cervical smears (p=0.015), with women whose partners tested positive for HPV having a higher prevalence of abnormal smears (47.1%) compared to those with HPV-negative partners (26.0%). While 16% of participants reported a history of smoking and 34% used oral contraceptives, neither factor showed a significant relationship with cervical abnormalities. The findings highlight the importance of partner HPV status in the development of cervical abnormalities and emphasize the need for focused HPV screening and preventive measures.
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1. Alamiraw, J. A., Asres, A. W., & Adella, G. A. (2020). Predictors of precancerous cervical lesions among women screened for cervical cancer in Bahir Dar Town, Ethiopia: A case–control study. Cancer Management and Research, 12, 6331-6339.
https://doi.org/10.2147/cmar.s258167
2. Bauer, M., et al. (2017). The role of HPV transmission between sexual partners in the development of cervical cancer. Journal of Clinical Oncology, 35(7), 521-527.
https://doi.org/10.1200/JCO.2016.69.5572
3. Bowden, S. J., Doulgeraki, T., Bouras, E., Markozannes, G., Athanasiou, A., Grout-Smith, H., Kechagias, K. S., Ellis, L. B., Zuber, V., Chadeau-Hyam, M., Flanagan, J. M., Tsilidis, K. K., Kalliala, I., & Kyrgiou, M. (2023). Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: An umbrella review and follow-up mendelian randomisation studies. BMC Medicine, 21(1).
https://doi.org/10.1186/s12916-023-02965-w
4. Brandt, T., Wubneh, S. B., Handebo, S., Debalkie, G., Ayanaw, Y., Alemu, K., ... & Bussmann, H. (2019). Genital self-sampling for HPV-based cervical cancer screening: a qualitative study of preferences and barriers in rural Ethiopia. BMC Public Health, 19(1), 1026.
https://doi.org/10.1186/s12889-019-7354-4
5. Mitro, S. D., Rozek, L. S., Vatanasapt, P., Suwanrungruang, K., Chitapanarux, I., Srisukho, S., Sriplung, H., & Meza, R. (2016). Iodine deficiency and thyroid cancer trends in three regions of Thailand, 1990–2009. Cancer Epidemiology, 43, 92–99.
https://doi.org/10.1016/j.canep.2016.07.002
6. Franco, E., et al. (2018). Oral contraceptive use and risk of cervical cancer: A systematic review and meta-analysis. Gynecologic Oncology, 149(1), 115-122.
https://doi.org/10.1016/j.ygyno.2018.03.011
7. Hanna, L., et al. (2015). Smoking and its impact on cervical dysplasia: A review of literature. Cancer Causes & Control, 26(11), 1501-1512.
https://doi.org/10.1007/s10552-015-0671-x
8. Huang, W., Xu, H., Hu, H., Zhang, D., Liu, Y., Guo, Y., Xiao, F., Chen, W., & Ma, Z. (2022). The prevalence of human papillomavirus among women in northern Guangdong province of China. Scientific Reports, 12(1).
https://doi.org/10.1038/s41598-022-17632-y
9. James, C. D., Morgan, I. M., & Bristol, M. L. (2020). The relationship between estrogen-related signaling and human papillomavirus positive cancers. Pathogens, 9(5), 403.
https://doi.org/10.3390/pathogens9050403
10. Kombe Kombe, A. J., Li, B., Zahid, A., Mengist, H. M., Bounda, G., Zhou, Y., & Jin, T. (2021). Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation. Frontiers in Public Health, 8.
https://doi.org/10.3389/fpubh.2020.552028
11. Megersa, B. S., Bussmann, H., Bärnighausen, T., Muche, A. A., Alemu, K., & Deckert, A. (2020). Community cervical cancer screening: Barriers to successful home-based HPV self-sampling in Dabat district, North Gondar, Ethiopia. A qualitative study. PLOS ONE, 15(12), e0243036.
https://doi.org/10.1371/journal.pone.0243036
12. Paolini, F., Amici, C., Carosi, M., Bonomo, C., Di Bonito, P., Venuti, A., & Accardi, L. (2021). Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors. Journal of Experimental & Clinical Cancer Research, 40, 1.
https://doi.org/10.1186/s13046-021-01988-y
13. Rao, C. R., & Rao, R. (2023). Impact of sexually transmitted diseases on public health. In Sexually Transmissible Oral Diseases (pp. 37-42). Springer.
https://doi.org/10.1007/978-3-030-85463-0_3
14. Rowley, J., Vander Hoorn, S., Korenromp, E., Low, N., Unemo, M., Abu-Raddad, L. J., Chico, R. M., Smolak, A., Newman, L., Gottlieb, S., Thwin, S. S. (2019). Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates, 2016. Bulletin of the World Health Organization, 97(8), 548.
https://doi.org/10.2471/BLT.18.223476
15. Sanjose, S., et al. (2021). The impact of smoking intensity on cervical cytology: A cohort study. International Journal of Cancer, 148(8), 1998-2006.
https://doi.org/10.1002/ijc.32001
16. Siegel, R. L., et al. (2019). Cancer statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7-34.
https://doi.org/10.3322/caac.21551
17. Smith, M., et al. (2018). The role of HPV and sexual behavior in cervical cancer development. International Journal of Gynecological Cancer, 28(6), 1080-1086.
https://doi.org/10.1097/IGC.0000000000001249
18. Temesgen, M. M., Alemu, T., Shiferaw, B., Legesse, S., Zeru, T., Haile, M., & Gelanew, T. (2021). Prevalence of oncogenic human papillomavirus (HPV 16/18) infection, cervical lesions and its associated factors among women aged 21–49 years in Amhara region, Northern Ethiopia. PLOS ONE, 16(3), e0248949.
https://doi.org/10.1371/journal.pone.0248949
19. Tesfaye, E., Kumbi, B., Mandefro, B., Hemba, Y., Prajapati, K. K., Singh, S. C., Upadhye, V., Hajare, S. T. (2024). Prevalence of human papillomavirus infection and associated factors among women attending cervical cancer screening in the setting of Addis Ababa, Ethiopia. Scientific Reports, 14(1), 4053.
https://doi.org/10.1038/s41598-024-38511-9
20. Yang, H.-X., Zhong, Y., Lv, W.-H., & Yu, H. (2019). Factors associated with human papillomavirus infection - findings from a cervical cancer screening program for female employees in Beijing. Cancer Management and Research, 11, 8033–8041.
https://doi.org/10.2147/CMAR.S209322
21. Zidi, S., Sahli, M., Amel Mezlini, & Besma Yacoubli-Loueslati. (2020). Association of Combined Tobacco Smoking, Hormonal Contraceptive use and Status Matrimonial with Cervical Cancer Evolution in Tunisian Women. Pathology & Oncology Research, 26(1), 217–222.
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