Comparison of Hypertonic Saline with Normal Saline Nebulization in the Management of Bronchiolitis in Children

Authors

  • Ayesha Riaz Department of Pediatrics, Hameed Latif Hospital, Lahore, Pakistan
  • Arfa Rafique Department of Pediatrics, Hameed Latif Hospital, Lahore, Pakistan
  • Muhammad Umer Younas Aziz Fatimah Hospital, Faisalabad, Pakistan
  • Muhammad Waqas Department of Plastic Surgery, Services Hospital, Lahore, Pakistan
  • Amna Abbas Department of Pediatrics, Hameed Latif Hospital, Lahore, Pakistan
  • Saed Aftab Ahmad Department of Pediatrics, Hameed Latif Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.70749/ijbr.v3i6.2001

Keywords:

bronchiolitis, children, clinical severity score, hypertonic saline, nebulization, normal saline

Abstract

Objective: “To compare the outcome of hypertonic saline with normal saline nebulization in management of bronchiolitis in children” Study design: Randomized controlled trial. Study place and duration: Department of Pediatrics, Hameed Latif Hospital, Lahore from 1st Oct 2024 to 15th April-2025. Methodology: Sixty infants fulfilling selection criteria were enrolled through emergency and were randomly divided in two groups. In group A, infants were given hypertonic (3%) saline nebulization. In group B, infants were given normal saline nebulization. Clinical severity score (CSS) was noted after 30, 60 and 120 minutes of nebulization and change in CSS was calculated. All the data was noted in proforma and analsyed in SPSS v.26. Results: At baseline, the median CSS score was 3.00 (IQR: 0.00) in bob groups, as all the infants has CSS score >2 at the time of presentation / enrolment. The median change after 30 minutes was observed as 1.00 (IQR: 1.00) with hypertonic saline and 1.00 (IQR: 0.25) with normal saline (p<0.05). The median change after 60 minutes was observed as 2.00 (IQR: 1.00) with hypertonic saline and 2.00 (IQR: 1.00) with normal saline (p<0.05). The median change after 120 minutes was observed as 3.00 (IQR: 1.00) with hypertonic saline and 2.00 (IQR: 0.25) with normal saline (p<0.05). Conclusion: The outcomes in terms of reduction in clinical severity score of bronchiolitis with hypertonic saline nebulization is better than normal saline nebulization.

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References

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Published

2025-06-30

Issue

Vol. 3 No. 6 (2025): Indus Journal of Bioscience Research

Section

Original Article

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Copyright (c) 2025 Indus Journal of Bioscience Research

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Riaz, A., Rafique, A., Younas, M. U., Muhammad Waqas, Abbas, A., & Ahmad, S. A. (2025). Comparison of Hypertonic Saline with Normal Saline Nebulization in the Management of Bronchiolitis in Children. Indus Journal of Bioscience Research, 3(6), 948-952. https://doi.org/10.70749/ijbr.v3i6.2001