Clinical Spectrum of Emergency Presentations in End-Stage Kidney Disease Patients on Hemodialysis: Experience from a Tertiary Care Center in Pakistan

Authors

  • Babar Aman Department of Emergency Medicine, Our Lady of Lourdes Hospital, Drogheda, Ireland.
  • Ali Raza Department of Nephrology, Khyber Teaching Hospital, Peshawar, KP, Pakistan.
  • Warda Zulfiqar Department of Internal Medicine, Khyber Teaching Hospital, Peshawar, KP, Pakistan.
  • Muhammad Waheed Sohail Department of Nephrology, Peshawar Institute of Cardiology, Peshawar, KP, Pakistan.
  • Fayaz Khan Department of Nephrology , Rahman Medical Institute , Peshawar, KP, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i6.2029

Keywords:

: End-stage Kidney Disease, Emergency Department, Hemodialysis, CKD Complications, ED Utilization

Abstract

Background: End-stage kidney disease (ESKD) is associated with high morbidity and frequent emergency department (ED) utilization due to acute complications. This study aimed to evaluate the clinical profile and causes of ED visits among ESKD patients undergoing maintenance hemodialysis at a tertiary nephrology center in Peshawar, Pakistan. Methods: A facility-based, cross-sectional study was conducted at Khyber Teaching Hospital from November 2024 to March 2025. A total of 384 adult patients on maintenance hemodialysis who presented to the ED were enrolled. Data were collected using a structured proforma and analyzed using SPSS v24. Results: Most patients were male (57.8%) and hypertensive (88.0%), with diabetes mellitus (50.5%) also common. The majority were on twice-weekly in-center dialysis using arteriovenous fistulae. Infection-related complications were the leading cause of ED visits (68.5%), with respiratory tract and access-related infections most common. Electrolyte imbalances, pulmonary edema, and cardiovascular emergencies were also frequent. Catheter use and suboptimal dialysis were associated with increased acute presentations. Conclusion: ESKD patients face a high burden of preventable complications. Improved outpatient monitoring, individualized dialysis plans, and better infection control measures are essential to reduce ED utilization and improve outcomes in this population.

Downloads

Download data is not yet available.

References

1. Jha, V., Garcia-Garcia, G., Iseki, K., Li, Z., Naicker, S., Plattner, B., Saran, R., Wang, A. Y., & Yang, C. (2013). Chronic kidney disease: Global dimension and perspectives. The Lancet, 382(9888), 260-272.

https://doi.org/10.1016/s0140-6736(13)60687-x

2. Collaborators, G. B. D. (2015). Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet, 385(9963), 117-171. https://doi.org/10.1016/s0140-6736(14)61682-2

3. Coresh, J. (2017). Update on the burden of CKD. Journal of the American Society of Nephrology, 28(4), 1020-1022.

https://doi.org/10.1681/asn.2016121374

4. Hasan, M., Sutradhar, I., Gupta, R. D., & Sarker, M. (2018). Prevalence of chronic kidney disease in South Asia: A systematic review. BMC Nephrology, 19(1).

https://doi.org/10.1186/s12882-018-1072-5

5. Webster, A. C., Nagler, E. V., Morton, R. L., & Masson, P. (2017). Chronic kidney disease. The Lancet, 389(10075), 1238-1252.

https://doi.org/10.1016/s0140-6736(16)32064-5

6. Komenda, P., Tangri, N., Klajncar, E., Eng, A., Di Nella, M., Hiebert, B., Strome, T., Lobato de Faria, R., Zacharias, J. M., Verrelli, M., Sood, M. M., & Rigatto, C. (2018). Patterns of emergency department utilization by patients on chronic dialysis: A population-based study. PLOS ONE, 13(4), e0195323.

https://doi.org/10.1371/journal.pone.0195323

7. Lovasik, B. P., Zhang, R., Hockenberry, J. M., Schrager, J. D., Pastan, S. O., Mohan, S., & Patzer, R. E. (2016). Emergency department use and hospital admissions among patients with end-stage renal disease in the United States. JAMA Internal Medicine, 176(10), 1563.

https://doi.org/10.1001/jamainternmed.2016.4975

8. Wang, N., Pei, J., Fan, H., Ali, Y., Prushinskaya, A., Zhao, J., & Zhang, X. (2021). Emergency department use by patients with end-stage renal disease in the United States. BMC Emergency Medicine, 21(1).

https://doi.org/10.1186/s12873-021-00420-8 .

9. Suhail, S., Raza, A., Ahmed, A. R., Marrium, B., & Mushtaq, W. (2025). The Etiological profile of chronic kidney disease patients presenting to nephrology division, khyber teaching hospital, Peshawar, Pakistan. Indus Journal of Bioscience Research, 3(7), 431-434.

https://doi.org/10.70749/ijbr.v3i7.1931

10. Sarnak, M. J., Levey, A. S., Schoolwerth, A. C., Coresh, J., Culleton, B., Hamm, L. L., McCullough, P. A., Kasiske, B. L., Kelepouris, E., Klag, M. J., Parfrey, P., Pfeffer, M., Raij, L., Spinosa, D. J., Wilson, P. W., & American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. (2003). Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation, 108(17), 2154–2169.

https://doi.org/10.1161/01.CIR.0000095676.90936.80

11. SciELO Brasil (2025). Metabolic acidosis in hemodialysis patients: a review Metabolic acidosis in hemodialysis patients: a review.

https://www.scielo.br/j/jbn/a/GN8d3NZZbmBPQTyfF4rw89P/

12. Mujtaba, F., Ahmad, A., Dhrolia, M., Qureshi, R., & Nasir, K. (2022). Causes of emergency department visits among end-stage kidney disease patients on maintenance hemodialysis in Pakistan: A single-center study. Cureus.

https://doi.org/10.7759/cureus.33004

13. Kumbar, L., & Yee, J. (2019). Current concepts in hemodialysis vascular access infections. Advances in Chronic Kidney Disease, 26(1), 16-22.

https://doi.org/10.1053/j.ackd.2018.10.005

14. Cozzolino, M., Mangano, M., Stucchi, A., Ciceri, P., Conte, F., & Galassi, A. (2018). Cardiovascular disease in dialysis patients. Nephrology Dialysis Transplantation, 33(suppl_3), iii28-iii34.

https://doi.org/10.1093/ndt/gfy174

Downloads

Published

2025-06-30

How to Cite

Aman, B., Raza, A., Zulfiqar, W., Sohail, M. W., & Khan, F. (2025). Clinical Spectrum of Emergency Presentations in End-Stage Kidney Disease Patients on Hemodialysis: Experience from a Tertiary Care Center in Pakistan. Indus Journal of Bioscience Research, 3(6), 986-990. https://doi.org/10.70749/ijbr.v3i6.2029