Use of Tokiyo Classification in Acute Cholecystitis

Authors

  • Ghulam Murtaza Ali Department of General Surgery, Surgical Unit-II, Holy Family Hospital, Rawalpindi, Pakistan.
  • Muhammad Ammar Aslam Department of General Surgery, Rawalpindi Medical University / Holy Family Hospital, Rawalpindi, Pakistan.
  • Muhammad Zaheer Department of General Surgery, Surgical Unit-II, Holy Family Hospital, Rawalpindi, Pakistan.
  • Nadeem Iqbal Department of General Surgery, Rawalpindi Medical University / Holy Family Hospital, Rawalpindi, Pakistan.
  • Shagufta Department of General Surgery, Rawalpindi Medical University / Holy Family Hospital, Rawalpindi, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i6.2378

Keywords:

Tokyo guidelines, acute cholecystitis, cholecystectomy.

Abstract

Objectives: To determine frequency of severity of acute cholecystitis by using Tokyo Guidelines. Study design: Descriptive, cross sectional study Settings: Surgical Unit-2, Holy Family Hospital, Rawalpindi. Study duration: ovember 2024 to April 2025. Materials & Methods: Total 152 patients between the ages of 20 and 40 years who had acute Cholecystitis were included, regardless of gender. Chronic cholecystitis with CBD stones, cholecystectomy due to biliary acute pancreatitis, liver disease, and prior abdominal surgery were not included, nor GB polypoid lesion and GB cancer. Severity of AC was assessed by according to the TGs. Patients were managed as per hospital protocol. Results: The study's participants ranged in age from 40 to 80, with a mean age of 47.95 ± 9.20 years.  Ninety-six (63.16%) of the patients were between the ages of 41 and 60.  With a male to female ratio of 1:1.5, 61 (40.13%) of the 152 patients were male and 91 (59.87%) were female. Mean BMI was 27.36 ± 2.94 kg/m2. In our study, there were 88 (57.89%) Grade I, 46 (30.26%) were Grade II and 18 (11.85%) were Grade III in accordance with the TGs. Conclusion: This study found that the prevalence and severity of acute cholecystitis can be ascertained using the Tokyo Guidelines.

Downloads

Download data is not yet available.

References

1. Adachi T, Eguchi S, Muto Y. Pathophysiology and pathology of acute cholecystitis: a secondary publication of the Japanese version from 1992. J Hepatobiliary Pancreat Sci. 2022;29:212-6.

https://doi.org/10.1002/jhbp.912

2. Barie P, Kao L, Moody M. Infection or inflammation: are uncomplicated acute appendicitis, acute cholecystitis, and acute diverticulitis infectious diseases? Surg Infect. 2023;24:99-111.

https://doi.org/10.1089/sur.2022.363

3. Affan RA, Noureldin AW, Jr MA. Classification and Management of Acute Cholangitis. Panam J Trauma, Crit Care Emerg Surg. 2022;11(3):163-8.

https://doi.org/10.5005/jp-journals-10030-1401

4. Sperna Weiland CJ, Busch CBE, Bhalla A. Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction. J Hepatobiliary Pancreat Sci. 2022;29(4):479–86.

https://doi.org/10.1002/jhbp.1096

5. Fugazzola P, Cobianchi L, Di Martino M. Prediction of morbidity and mortality after early cholecystectomy for acute calculous cholecystitis: results of the S.P.Ri.M.A.C.C. study. World J Emerg Surg. 2023;18:20.

https://doi.org/10.21203/rs.3.rs-2370414/v1

6. Adachi T, Eguchi S, Muto Y. Pathophysiology and pathology of acute cholecystitis: A secondary publication of the Japanese version from 1992. J. Hepatobiliary Pancreat. Sci. 2021;29:212–16.

https://doi.org/10.1002/jhbp.912

7. Park TY, Do JH, Oh HC, Choi YS, Lee SE, Kang H, et al. Relationship between the tokyo guidelines and pathological severity in acute cholecystitis. J Personalized Med. 2023;13(9):1335-41.

https://doi.org/10.3390/jpm13091335

8. Shridhar M, Shivakumar M, Satish HT, Nutan BV, Diggi A. Effectiveness of tokyoguidelines 2018 in the management of acute cholangitis and acute cholecystitis. Int J Adv Res. 2023;11(05):175-87.

https://doi.org/10.21474/ijar01/16866

9. Morikawa T, Akada M, Shimizu M, Nishida Y, Izai J, Kajioka H, et al. Current status and therapeutic strategy of acute acalculous cholecystitis: Japanese nationwide survey in the era of the Tokyo guidelines. J Hepatobiliary Pancreat Sci. 2024;31:162–72.

https://doi.org/10.1002/jhbp.1401

10. Rao KS, Meghavathu G, Rao S, Prasad T. Clinical study of gallstone disease and treatment options. J Evo Med Dental Sci. 2015;4(79):13841-8.

https://doi.org/10.14260/jemds/2015/1972

11. Hermann RE. “Biliary disease in the aging patients”. New York: Masson; 1983: 227-32. 16. Motiwala HG. Operative technique of cholecystectomy: A study of 250 cases. Macmillan India Limited, 1991;204.

12. Ganey JB, Johnson PA, Jr, Prillaman PE, McSwain GR. Cholecystectomy: clinical experience with a large series. Am J Surg. 1986;151(3):352-7.

https://doi.org/10.1016/0002-9610(86)90466-6

13. Moreaux J. Prospective study of open cholecystectomy for calculous biliary disease. Br J Surg. 1994;81(1):116-9.

https://doi.org/10.1002/bjs.1800810142

14. Jayanthi V, Prasanthi R, Surendran R, Palanivelu C. Epidemiology of gall stone disease. BHJ. 2020;5:786- 9.

15. Liu CM, Tung TH, Chou P, Chen VTK, Hsu CT, Chien WS, et al. Clinical correlation of gallstone disease in a Chinese population in Taiwan: Experience at Cheng Hsin General Hospital. World J Gastroenterol. 2006;12(8):1281-98.

https://doi.org/10.3748/wjg.v12.i8.1281

16. Iqbal A, Shah FH, Gani M, Naqash SH, Shah MA. Assessing the severity grading of acute cholecystitis according to Tokyo guidelines 2013 and outcome of conservative management. Int J Res Med Sci. 2025;13:1482-7.

https://doi.org/10.18203/2320-6012.ijrms20250969

17. Yokoe M, Takada T, Hwang TL, Endo I, Akazawa K, Miura F, et al. Validation of TG13 severity grading in acute cholecystitis: Japan-Taiwan collaborative study for acute cholecystitis. J Hepatobiliary Pancreat Sci. 2017;24:338–45.

https://doi.org/10.1002/jhbp.457

18. Asai K, Iwashita Y, Ohyama T, Endo I, Hibi T, Umezawa A, et al. Application of a novel surgical difficulty grading system during laparoscopic cholecystectomy. J Hepatobiliary Pancreat Sci. 2022;29:758–67.

https://doi.org/10.1002/jhbp.1068

19. Janssen ERI, Hendriks T, Natroshvili T, Bremers AJA. Retrospective analysis of non-surgical treatment of acute cholecystitis. Surg Infect (Larchmt). 2020;21(5):428-32.

https://doi.org/10.1089/sur.2019.261

20. Donohue SJ, Reinke CE, Evans SL, Jordan MM, Warren YE, Hetherington T, et al. Laparoscopy is associated with decreased all-cause mortality in patients undergoing emergency general surgery procedures in a regional health system. Surg Endosc. 2022;36:3822–32.

https://doi.org/10.1007/s00464-021-08699-1

21. Cook MD, Karim SA, Jensen HK, Bennett JL, Burdine LJ, Bhavaraju A, et al. Percutaneous cholecystostomy tubes versus medical management for acute cholecystitis. Am Surg. 2022;88:828–33.

https://doi.org/10.1177/00031348211054567

Downloads

Published

2025-06-30

How to Cite

Ali, G. M., Aslam, M. A., Muhammad Zaheer, Iqbal, N., & Shagufta. (2025). Use of Tokiyo Classification in Acute Cholecystitis. Indus Journal of Bioscience Research, 3(6), 1164-1167. https://doi.org/10.70749/ijbr.v3i6.2378