Green Synthesis of Turmuric by Using Curcumin Conjugated Cerium (CU-CE-CUO-NP) Nanoparticles and Evaluation of Antibacterial and Anticancer Activity
DOI:
https://doi.org/10.70749/ijbr.v4i1.2825Keywords:
Nanoparticles, Curcumin, MTT assay, Anticancer agent, Drug delivery agentAbstract
This study explores the multifaceted properties of synthesized Copper-Cerium Nano Particles (Cu-Ce NPs) and their potential applications in medicine, healthcare, and biotechnology. The antioxidative potential of Cu-Ce NPs was assessed through DPPH and NO radical scavenging assays, revealing their ability to scavenge free radicals effectively. A positive correlation between Cu-Ce NP concentration and scavenging percentage was observed, with concentrations as low as 15 µg/mL displaying significant antioxidative activity and reaching a peak of 54.10% at 450 µg/mL. These findings indicate that Cu-Ce NPs possess strong antioxidant properties, essential for combating oxidative stress-related health issues.The study also highlighted the antibacterial efficacy of Cu-Ce NPs derived from turmeric leaves against both Gram-negative (E. coli) and Gram-positive (Bacillus subtilis) bacteria. Clear inhibition zones in agar well diffusion assays demonstrated their potential as antibacterial agents. Confirmation of antibacterial activity was obtained through culture-based methods, further substantiating the broad-spectrum antibacterial properties of Cu-Ce-Cuo NPs. Furthermore, Cur-Ce-CuO NPs were successfully synthesized and characterized, revealing the conjugation of curcumin with copper-cerium oxide nanoparticles. The possibility of inhibiting cancer cell proliferation was demonstrated through MTT assays, suggesting potential anticancer properties. In conclusion, Cu-Ce-Cuo NPs exhibit versatile properties, including antioxidative potential, antibacterial activity, and anticancer effects. These properties position them as promising therapeutic agents, offering solutions to health challenges and medical treatments. Further research and development hold the potential to unlock new avenues for addressing critical health issues and enhancing medical interventions.
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