Silver-Decorated 2D Nanomaterials for Rapid and Broad-Spectrum Antibacterial Applications
DOI:
https://doi.org/10.70749/ijbr.v4i3.2948Keywords:
Silver Nanoparticles, 2D Nanomaterials, Antibacterial Activity, Nanocomposite.Abstract
Nanomaterials based on silver have become the focus of attention because of their excellent bactericidal effects and low chance of resistance occurring. Two-dimensional (2D) nanomaterials with silver decoration were prepared in this study and evaluated based on their speedy and universal antibacterial activity. X-ray diffraction (XRD), Fourier-transform infrared spectrophotometry (FTIR), and UV-Visible spectra were used to perform structural and physicochemical characterization of the silver nanoparticles to verify the success of the formation and stabilization of the material on the 2D substrate. The XRD pattern indicated that the crystal structure of metallic silver was face-centered cubic crystal and the FTIR analysis indicated that functional groups that anchored the nanoparticles were present. The spectroscopy UV Vis observed a typical surface plasmon resonance peak at 420 nm, which reflected that the silver nanoparticles were well dispersed. The discovery of nanocomposite synthesized was tested against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus by disc diffusion. The findings showed that they have a potent concentration-related antibacterial effect, and the silver-decorated 2D nanomaterials were the promising candidates to the development of the advanced antimicrobial applications.
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1. Sharma, S., Chauhan, A., Ranjan, A., Mathkor, D. M., Haque, S., Ramniwas, S., Tuli, H. S., Jindal, T., & Yadav, V. (2024). Emerging challenges in antimicrobial resistance: Implications for pathogenic microorganisms, novel antibiotics, and their impact on sustainability. Frontiers in Microbiology, 15.
https://doi.org/10.3389/fmicb.2024.1403168
2. Muteeb, G., Rehman, M. T., Shahwan, M., & Aatif, M. (2023). Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review. Pharmaceuticals, 16(11), 1615.
https://doi.org/10.3390/ph16111615
3. Kaye, K. S., & Pogue, J. M. (2015). Infections caused by resistant Gram‐negative bacteria: Epidemiology and management. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 35(10), 949-962.
https://doi.org/10.1002/phar.1636
4. Baker, S. J., Payne, D. J., Rappuoli, R., & De Gregorio, E. (2018). Technologies to address antimicrobial resistance. Proceedings of the National Academy of Sciences, 115(51), 12887–12895.
https://doi.org/10.1073/pnas.1717160115
5. Gherasim, O., Puiu, R. A., Bîrcă, A. C., Burdușel, A., & Grumezescu, A. M. (2020). An updated review on silver nanoparticles in biomedicine. Nanomaterials, 10(11), 2318.
https://doi.org/10.3390/nano10112318
6. Martínez-Gutierrez, F., Thi, E. P., Silverman, J. M., de Oliveira, C. C., Svensson, S. L., Hoek, A. V., Sánchez, E. M., Reiner, N. E., Gaynor, E. C., Pryzdial, E. L., Conway, E. M., Orrantia, E., Ruiz, F., Av-Gay, Y., & Bach, H. (2012). Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 8(3), 328-336.
https://doi.org/10.1016/j.nano.2011.06.014
7. Dwivedi, M., Parmar, M. D., Mukherjee, D., Yadava, A., Yadav, H., & Saini, N. P. (2024). Biochemistry, mechanistic intricacies, and therapeutic potential of antimicrobial peptides: An alternative to traditional antibiotics. Current Medicinal Chemistry, 31(37), 6110-6139.
https://doi.org/10.2174/0109298673268458230926105224
8. Mei, L., Zhu, S., Yin, W., Chen, C., Nie, G., Gu, Z., & Zhao, Y. (2020). Two-dimensional nanomaterials beyond graphene for antibacterial applications: Current progress and future perspectives. Theranostics, 10(2), 757-781.
https://doi.org/10.7150/thno.39701
9. Guo, Y., Xu, K., Wu, C., Zhao, J., & Xie, Y. (2015). Surface chemical-modification for engineering the intrinsic physical properties of inorganic two-dimensional nanomaterials. Chemical Society Reviews, 44(3), 637-646.
https://doi.org/10.1039/c4cs00302k
10. Waychunas, G. A. (2001). 4. Structure, aggregation and characterization of nanoparticles. Nanoparticles and the Environment, 105-166.
https://doi.org/10.1515/9781501508783-008
11. Qadir, A., Le, T. K., Malik, M., Amedome Min-Dianey, K. A., Saeed, I., Yu, Y., Choi, J. R., & Pham, P. V. (2021). Representative 2D-material-based nanocomposites and their emerging applications: A review. RSC Advances, 11(39), 23860-23880.
https://doi.org/10.1039/d1ra03425a
12. Li, X., Zhao, X., Chu, D., Zhu, X., Xue, B., Chen, H., Zhou, Z., & Li, J. (2022). Silver nanoparticle-decorated 2D Co-TCPP MOF nanosheets for synergistic photodynamic and silver ion antibacterial. Surfaces and Interfaces, 33, 102247.
https://doi.org/10.1016/j.surfin.2022.102247
13. Saqib Munir, M., Imran Alvi, M., Adnan Saeed, M., Khan, A., Shareef, A., & Khan, M. (2025). Functionalization and unlocking the potential of silver-decorated multiwall carbon nanotubes for optoelectronic devices and anti-bacterial applications. Materials Chemistry and Physics: Sustainability and Energy, 2, 100007.
https://doi.org/10.1016/j.macse.2024.100007
14. Díez-Pascual, A. M. (2020). Antibacterial action of Nanoparticle loaded Nanocomposites based on Graphene and its derivatives: A mini-review. International Journal of Molecular Sciences, 21(10), 3563.
https://doi.org/10.3390/ijms21103563
15. Sahoo, J., Sarkhel, S., Mukherjee, N., & Jaiswal, A. (2022). Nanomaterial-based antimicrobial coating for biomedical implants: New age solution for biofilm-associated infections. ACS Omega, 7(50), 45962-45980.
https://doi.org/10.1021/acsomega.2c06211
16. Munir, M. U., Ahmed, A., Usman, M., & Salman, S. (2020).
Recent advances in nanotechnology-aided materials in combating microbial resistance and functioning as antibiotics Substitutes
. International Journal of Nanomedicine, 15, 7329-7358.https://doi.org/10.2147/ijn.s265934
17. Franci, G., Falanga, A., Galdiero, S., Palomba, L., Rai, M., Morelli, G., & Galdiero, M. (2015). Silver nanoparticles as potential antibacterial agents. Molecules, 20(5), 8856-8874.
https://doi.org/10.3390/molecules20058856
18. Vila Domínguez, A., Ayerbe Algaba, R., Miró Canturri, A., Rodríguez Villodres, Á., & Smani, Y. (2020). Antibacterial activity of colloidal silver against Gram-negative and Gram-positive bacteria. Antibiotics, 9(1), 36.
https://doi.org/10.3390/antibiotics9010036
19. Tang, S., & Zheng, J. (2018). Antibacterial activity of silver nanoparticles: Structural effects. Advanced Healthcare Materials, 7(13).
https://doi.org/10.1002/adhm.201701503
20. Mei, L., Zhu, S., Yin, W., Chen, C., Nie, G., Gu, Z., & Zhao, Y. (2020). Two-dimensional nanomaterials beyond graphene for antibacterial applications: Current progress and future perspectives. Theranostics, 10(2), 757-781.
https://doi.org/10.7150/thno.39701
21. Malik, S. B., Saggu, J. I., Gul, A., Abbasi, B. A., Iqbal, J., Waris, S., Jardan, Y. A., & Chalgham, W. (2022). Synthesis and characterization of silver and Graphene Nanocomposites and their antimicrobial and photocatalytic potentials. Molecules, 27(16), 5184.
https://doi.org/10.3390/molecules27165184
22. Liu, J., Li, S., Fang, Y., & Zhu, Z. (2019). Boosting Antibacterial Activity with Mesoporous Silica Nanoparticles Supported Silver Nanoclusters. Journal of Colloid and Interface Science.
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