Opioid-Sparing Analgesic Protocols in Postoperative Pain: A Retrospective Study

Authors

  • Asifa Saeed Department of Anesthesia and ICU, Allied Hospital 1, FMU Faisalabad, Pakistan
  • Ayesha Yousaf Department of Anesthesia, Allied Hospital Faisalabad, Pakistan
  • Muhammad Subed Ali Department of Trauma and Orthopaedics, Pinderfields Hospital, Mid Yorkshire Teaching NHS Trust, UK
  • Azmeer Aamir Department of Internal Medicine, Mercy Teaching Hospital, Peshawar, Pakistan.
  • Mohammad Yahya Department of Medical Education, Abu Umara Medical and Dental College, Green International University, Lahore, Pakistan
  • Syeda Hadiqa Hassan Department of Biochemistry, Queen's Medical College Kasur, Pakistan
  • Asma Arshad Department of Gynaecology and Obstetrics, Fatima Memorial Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.70749/ijbr.v4i3.2975

Keywords:

Opioid-sparing analgesia, postoperative pain, multimodal analgesia, opioid consumption

Abstract

Background: Postoperative pain management remains a critical component of surgical care, with opioids traditionally serving as the mainstay of analgesia. Objective: To compare the effectiveness of opioid-sparing analgesic protocols with conventional opioid-based analgesia in terms of postoperative pain control, opioid consumption, recovery outcomes, and complications. Study Design: Retrospective comparative study. Place and Duration of Study: The study was conducted at Allied Hospital Faisalabad from June, 2025 November, 2025. Methodology: A total of 125 patients aged 18–70 years who underwent elective surgical procedures were included. Patients were divided into two groups based on analgesic protocol: opioid-sparing and conventional opioid-based analgesia. Data were retrieved from medical records, including demographic variables, postoperative pain scores (VAS), total opioid consumption within 24 hours, time to mobilization, length of hospital stay, and opioid-related complications. Data were analyzed using SPSS version 26. Results: The mean postoperative VAS score at 24 hours was significantly lower in the opioid-sparing group (3.2 ± 1.1) compared to the conventional group (4.5 ± 1.3) (p < 0.001). Total opioid consumption was also significantly reduced in the opioid-sparing group (18.6 ± 6.4 mg vs 32.8 ± 8.7 mg, p < 0.001). Patients receiving opioid-sparing analgesia demonstrated earlier mobilization (14.2 ± 5.6 vs 20.5 ± 7.3 hours, p = 0.002) and shorter hospital stay (3.1 ± 1.2 vs 4.6 ± 1.5 days, p = 0.001).  Conclusion: Opioid-sparing analgesic protocols provide superior pain control, reduce opioid requirements, enhance recovery, and minimize complications compared to conventional opioid-based analgesia.

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Published

2026-03-30

How to Cite

Saeed, A., Yousaf, A., Ali, M. S., Aamir, A., Mohammad Yahya, Hassan, S. H., & Arshad, A. (2026). Opioid-Sparing Analgesic Protocols in Postoperative Pain: A Retrospective Study. Indus Journal of Bioscience Research, 4(3), 43-47. https://doi.org/10.70749/ijbr.v4i3.2975