Frailty as Predictor of Outcomes in Cardiac Surgery

Authors

  • Wajiha Arshad Department of Cardiac Surgery, Rawalpindi Institute of Cardiology, Rawalpindi, Punjab, Pakistan.
  • Muhammad Sohail Chaudhri Department of Cardiac Surgery, Rawalpindi Institute of Cardiology, Rawalpindi, Punjab, Pakistan.
  • Alifa Sabir Department of Cardiac Surgery, Rawalpindi Institute of Cardiology, Rawalpindi, Punjab, Pakistan.
  • Sahab Ahmad Department of Cardiac Surgery, Rawalpindi Institute of Cardiology, Rawalpindi, Punjab, Pakistan.
  • Muhammad Azam Department of Cardiac Surgery, Rawalpindi Institute of Cardiology, Rawalpindi, Punjab, Pakistan.
  • Musfireh Siddiqeh Department of Cardiac Surgery, Rawalpindi Institute of Cardiology, Rawalpindi, Punjab, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i6.3009

Keywords:

Frailty, Cardiac Surgery, CABG, Outcomes, Modified Frailty Index.

Abstract

Objective: To determine the effectiveness of frailty index as a predictor of outcomes after cardiac surgery. Study Design: Cross-sectional study. Place and Duration of Study: Department of Cardiac Surgery, Rawalpindi Institute of Cardiology, Rawalpindi, over six months (July to December 2024). Methodology: A total of 376 patients undergoing elective cardiac surgery were included using simple random sampling. Frailty was assessed using a modified frailty index (deficit-based model with 9 variables) and categorized into non-frail, pre-frail, frail, and severely frail groups. Data were analyzed using SPSS version 25. Quantitative variables were expressed as mean ± SD and qualitative variables as frequency and percentages. Statistical significance was set at p ≤ 0.05. Results: The mean age was 51.26 ± 11.84 years, with 78.2% males. Frailty prevalence (pre-frail + frail) was 49.5%. Increasing frailty was significantly associated with higher postoperative complications, increased chest drainage, and mortality (p < 0.05). Frailty score independently predicted adverse outcomes (OR = 2.85, p = 0.001). Conclusion: Frailty is an independent predictor of adverse outcomes after cardiac surgery and should be incorporated into routine preoperative risk stratification.

Downloads

Download data is not yet available.

References

1. Afilalo, J., Alexander, K. P., Mack, M. J., Maurer, M. S., Green, P., Allen, L. A., Popma, J. J., Ferrucci, L., & Forman, D. E. (2014). Frailty assessment in the cardiovascular care of older adults. Journal of the American College of Cardiology, 63(8), 747-762.

https://doi.org/10.1016/j.jacc.2013.09.070

2. Bagshaw, S. M., Stelfox, H. T., McDermid, R. C., Rolfson, D. B., Tsuyuki, R. T., Baig, N., Artiuch, B., Ibrahim, Q., Stollery, D. E., Rokosh, E., & Majumdar, S. R. (2013). Association between frailty and short- and long-term outcomes among critically ill patients: A multicentre prospective cohort study. Canadian Medical Association Journal, 186(2), E95-E102.

https://doi.org/10.1503/cmaj.130639

3. Sepehri, A., Beggs, T., Hassan, A., Rigatto, C., Shaw-Daigle, C., Tangri, N., & Arora, R. C. (2014). The impact of frailty on outcomes after cardiac surgery: A systematic review. The Journal of Thoracic and Cardiovascular Surgery, 148(6), 3110-3117.

https://doi.org/10.1016/j.jtcvs.2014.07.087

4. Rockwood, K. (2005). A global clinical measure of fitness and frailty in elderly people. Canadian Medical Association Journal, 173(5), 489-495.

https://doi.org/10.1503/cmaj.050051

5. Graham, A., & Brown, C. H. (2017). Frailty, aging, and cardiovascular surgery. Anesthesia & Analgesia, 124(4), 1053-1060.

https://doi.org/10.1213/ane.0000000000001560

6. Reichart, D., Rosato, S., Nammas, W., Onorati, F., Dalén, M., Castro, L., Gherli, R., Gatti, G., Franzese, I., Faggian, G., De Feo, M., Khodabandeh, S., Santarpino, G., Rubino, A. S., Maselli, D., Nardella, S., Salsano, A., Nicolini, F., Zanobini, M., … Biancari, F. (2018). Clinical frailty scale and outcome after coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery, 54(6), 1102-1109.

https://doi.org/10.1093/ejcts/ezy222

7. Nakano, M., Nomura, Y., Suffredini, G., Bush, B., Tian, J., Yamaguchi, A., Walston, J., Hasan, R., Mandal, K., Schena, S., Hogue, C. W., & Brown, C. H. (2020). Functional outcomes of frail patients after cardiac surgery: An observational study. Anesthesia & Analgesia, 130(6), 1534-1544.

https://doi.org/10.1213/ane.0000000000004786

8. Hewitt, J., Long, S., Carter, B., Bach, S., McCarthy, K., & Clegg, A. (2018). The prevalence of frailty and its association with clinical outcomes in general surgery: A systematic review and meta-analysis. Age and Ageing, 47(6), 793-800.

https://doi.org/10.1093/ageing/afy110

9. Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., & McBurnie, M. A. (2001). Frailty in older adults: Evidence for a phenotype. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(3), M146-M157.

https://doi.org/10.1093/gerona/56.3.m146

10. Chandiramani, A., & Ali, J. M. (2025). Frailty in cardiac surgery—Assessment tools, impact on outcomes, and optimisation strategies: A narrative review. Journal of Cardiovascular Development and Disease, 12(4), 127.

https://doi.org/10.3390/jcdd12040127

11. Velanovich, V., Antoine, H., Swartz, A., Peters, D., & Rubinfeld, I. (2013). Accumulating deficits model of frailty and postoperative mortality and morbidity: Its application to a national database. Journal of Surgical Research, 183(1), 104-110.

https://doi.org/10.1016/j.jss.2013.01.021

12. Kim, S., Sakowitz, S., Hadaya, J., Curry, J., Chervu, N. L., Bakhtiyar, S. S., Mallick, S., Cho, N. Y., & Benharash, P. (2023). Association of frailty with postoperative outcomes following thoracic transplantation: A national analysis. JTCVS Open, 16, 1038-1048.

https://doi.org/10.1016/j.xjon.2023.10.011

13. Ahuja, A., Baker, T., & Ramanan, M. (2025). Impact of frailty on outcomes after cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery, 169(6), 1787-1794.e9.

https://doi.org/10.1016/j.jtcvs.2024.05.025

14. Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013). Frailty in elderly people. The Lancet, 381(9868), 752-762.

https://doi.org/10.1016/s0140-6736(12)62167-9

15. Chen, S., Zhang, S., Cai, S., & Wang, H. (2024). Impact of frailty on outcomes following coronary artery bypass grafting: A systematic review and meta-analysis. BMC Surgery, 24(1).

https://doi.org/10.1186/s12893-024-02728-1

16. Percy, E. D., Faggion Vinholo, T., Newell, P., Singh, S., Hirji, S., Awtry, J., Semco, R., Chowdhury, M., Reed, A. K., Asokan, S., Malarczyk, A., Okoh, A., Harloff, M., Yazdchi, F., Kaneko, T., & Sabe, A. A. (2024). The impact of frailty on outcomes of proximal aortic aneurysm surgery: A nationwide analysis. Journal of Cardiovascular Development and Disease, 11(1), 32.

https://doi.org/10.3390/jcdd11010032

17. Ahuja, A., Baker, T., & Ramanan, M. (2025). Impact of frailty on outcomes after cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery, 169(6), 1787-1794.e9.

https://doi.org/10.1016/j.jtcvs.2024.05.025

Downloads

Published

2025-06-30

How to Cite

Arshad, W., Chaudhri, M. S., Sabir, A., Ahmad, S., Muhammad Azam, & Siddiqeh, M. (2025). Frailty as Predictor of Outcomes in Cardiac Surgery. Indus Journal of Bioscience Research, 3(6), 1367-1370. https://doi.org/10.70749/ijbr.v3i6.3009