Correlation Between Carotid Intima-Media Thickness and Modified Gensini Score in Acute Coronary Syndrome Patients at a Tertiary Care Hospital
DOI:
https://doi.org/10.70749/ijbr.v3i6.3016Keywords:
CIMT, modified Gensini score, Atherosclerosis, Acute coronary syndrome, Coronary artery disease, B-mode ultrasonographyAbstract
Background: Cardiovascular disease remains a leading cause of mortality globally, with acute coronary syndrome (ACS) being a critical manifestation. carotid intima-media thickness (CIMT), measured via B-mode ultrasonography, has emerged as a non-invasive marker of systemic atherosclerosis. The modified Gensini score, derived from coronary angiographic findings, is a validated measure of coronary artery disease (CAD) severity. Establishing a correlation between these two parameters may allow CIMT to serve as a surrogate for assessing coronary artery atherosclerotic burden. Objective: To determine the correlation between CIMT measured on B-mode ultrasonography and the modified Gensini score in patients with ACS. Methods: This descriptive cross-sectional study was conducted at Benazir Bhutto Hospital, Rawalpindi. A total of 170 patients diagnosed with ACP were initially enrolled. After applying exclusion criteria—eliminating 37 patients with diabetes mellitus or hypertension a final sample of 133 patients aged 35–75 years was included. CIMT was measured bilaterally using high-resolution B-mode ultrasonography. Coronary angiograms were reviewed to calculate the modified Gensini score. Data were analyzed using SPSS version 25. Pearson’s correlation coefficient was used to assess the relationship between CIMT and Gensini scores. A p < 0.05 was considered statistically significant. Results: Among 133 patients, 69.9% were male and 30.1% female. The mean CIMT was 0.85 ± 0.15 mm, and the mean modified Gensini score was 34.7 ± 12.4. A significant positive correlation was observed between CIMT and Gensini score (r = 0.612, p < 0.001), indicating that higher CIMT values were associated with more severe coronary artery disease. Conclusion: There is a significant correlation between CIMT and the severity of coronary artery disease, as assessed by the modified Gensini score in patients with ACS. with the severity of coronary artery disease as assessed by the modified Gensini score in ACS patients. These findings support the role of CIMT as a non-invasive and reliable marker for estimating atherosclerotic burden, particularly in clinical settings where coronary angiography is not readily accessible.
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