Clinical Audit on Fever Workup and Timeliness of Antibiotics Administration in Febrile Patients
DOI:
https://doi.org/10.70749/ijbr.v4i3.3032Keywords:
Fever, Antibiotic Timing, Clinical Audit, Emergency Department, Sepsis.Abstract
Fever is a common presenting complaint in emergency departments and may indicate infections ranging from mild illness to sepsis. Early antibiotic administration is essential, with international guidelines recommending delivery within one hour of clinical suspicion to improve outcomes. A second-cycle closed-loop clinical audit was conducted in a high-volume tertiary care hospital to assess improvements in timeliness of antibiotic administration. A total of 362 febrile patients were included. Interventions after first cycle included staff training standardized fever protocols and real-time monitoring systems. Key outcomes were adherence to one-hour antibiotic benchmark and time intervals across care pathway. Adherence improved from 40% to 75% (p < 0.001). Mean time from diagnosis to antibiotic administration decreased from 95 minutes to 60 minutes while arrival-to-antibiotic time reduced by 41 minutes. Documentation improved and variability decreased. Gender-based disparities were eliminated. However, 25% still experienced delays due to high volume and workflow inefficiencies. System-level interventions significantly improved compliance with time-sensitive guidelines. Persistent delays highlight need for ongoing optimization and monitoring. Workflow redesign and rapid diagnostics are required to eliminate delays and achieve compliance. Audit cycles in clinical governance ensure efficiency and accountability in emergency care. This audit confirms structured interventions improve timely antibiotic administration in febrile patients and supports continuous quality improvement for guideline adherence. Ongoing monitoring leadership engagement and resource optimization remain essential to sustain gains and further reduce delays ensuring consistent high-quality emergency care delivery aligned with international standards across all patient groups consistently achieved.
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1. Alsabri, M., Onyejesi, C. D., Patel, A., Elewa, M., Abady, E. M., Mohunsing, R., Okolie, C. J., Zehra, S. A., & Lusinski, E. (2025). Optimizing fever management in pediatric emergency medicine: Pathophysiology, diagnostics, and evidence-based strategies. International Journal of Emergency Medicine, 18(1).
https://doi.org/10.1186/s12245-025-01014-y
2. Grundy, B. S., & Houpt, E. R. (2022). Opportunities and challenges to accurate diagnosis and management of acute febrile illness in adults and adolescents: A review. Acta Tropica, 227, 106286.
https://doi.org/10.1016/j.actatropica.2021.106286
3. Osborn, J., Roberts, T., Guillen, E., Bernal, O., Roddy, P., Ongarello, S., Sprecher, A., Page, A., Ribeiro, I., Piriou, E., Tamrat, A., De la Tour, R., Rao, V. B., Flevaud, L., Jensen, T., McIver, L., Kelly, C., & Dittrich, S. (2020). Prioritising pathogens for the management of severe febrile patients to improve clinical care in low- and middle-income countries. BMC Infectious Diseases, 20(1).
https://doi.org/10.1186/s12879-020-4834-1
4. Corsini, R., Marini, G., Ottone, M., Rossi, P. G., Lattuada, I. M., Cocchi, V., Lucchesi, D. M., Cacciamani, B., Beneventi, S., Cantergiani, S., Romani, F., Simion, M., Russello, G., & Mezzadri, S. (2025). Sepsis in the emergency department: A dual challenge of early management and antimicrobial stewardship. BMC Infectious Diseases, 25(1).
https://doi.org/10.1186/s12879-025-11947-7
5. Rothrock, S. G., Cassidy, D. D., Barneck, M., Schinkel, M., Guetschow, B., Myburgh, C., Nguyen, L., Earwood, R., Nanayakkara, P. W., Nannan Panday, R. S., & Briscoe, J. G. (2020). Outcome of immediate versus early antibiotics in severe sepsis and septic shock: A systematic review and meta-analysis. Annals of Emergency Medicine, 76(4), 427-441.
https://doi.org/10.1016/j.annemergmed.2020.04.042
6. Niederman, M. S., Baron, R. M., Bouadma, L., Calandra, T., Daneman, N., DeWaele, J., Kollef, M. H., Lipman, J., & Nair, G. B. (2021). Initial antimicrobial management of sepsis. Critical Care, 25(1).
https://doi.org/10.1186/s13054-021-03736-w
7. Im, Y., Kang, D., Ko, R., Lee, Y. J., Lim, S. Y., Park, S., Na, S. J., Chung, C. R., Park, M. H., Oh, D. K., Lim, C., Suh, G. Y., Lim, C., Hong, S., Oh, D. K., Suh, G. Y., Jeon, K., Ko, R., & Moon, J. Y. (2022). Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: A prospective nationwide multicenter cohort study. Critical Care, 26(1).
https://doi.org/10.1186/s13054-021-03883-0
8. Nauclér, P., Huttner, A., Van Werkhoven, C., Singer, M., Tattevin, P., Einav, S., & Tängdén, T. (2021). Impact of time to antibiotic therapy on clinical outcome in patients with bacterial infections in the emergency department: Implications for antimicrobial stewardship. Clinical Microbiology and Infection, 27(2), 175-181.
https://doi.org/10.1016/j.cmi.2020.02.032
9. Kollef, M. H., Shorr, A. F., Bassetti, M., Timsit, J., Micek, S. T., Michelson, A. P., & Garnacho-Montero, J. (2021). Timing of antibiotic therapy in the ICU. Critical Care, 25(1).
https://doi.org/10.1186/s13054-021-03787-z
10. Weiss, S. L., Peters, M. J., Agus, M. S., Alhazzani, W., Choong, K., Flori, H. R., Inwald, D. P., Nadel, S., Nunnally, M. E., Schlapbach, L. J., Tasker, R. C., Tissieres, P., & Kissoon, N. (2020). Perspective of the surviving sepsis campaign on the management of pediatric sepsis in the era of coronavirus disease 2019*. Pediatric Critical Care Medicine, 21(11), e1031-e1037.
https://doi.org/10.1097/pcc.0000000000002553
11. Van de Maat, J., Jonkman, H., Van de Voort, E., Mintegi, S., Gervaix, A., Bressan, S., Moll, H., & Oostenbrink, R. (2020). Measuring vital signs in children with fever at the emergency department: An observational study on adherence to the NICE recommendations in Europe. European Journal of Pediatrics, 179(7), 1097-1106.
https://doi.org/10.1007/s00431-020-03601-y
12. McCallum, A. D., & Brent, A. J. (2026). Sepsis. Medicine, 54(2), 124-129.
https://doi.org/10.1016/j.mpmed.2025.11.005
13. Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., ... & Levy, M. (2021). Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Critical care medicine, 49(11), e1063-e1143.
https://doi.org/10.1097/CCM.0000000000005337
14. Darraj, A., Hudays, A., Hazazi, A., Hobani, A., & Alghamdi, A. (2023). The association between emergency department overcrowding and delay in treatment: A systematic review. Healthcare, 11(3), 385.
https://doi.org/10.3390/healthcare11030385
15. Taylor, S. P., Shah, M., Kowalkowski, M. A., Taylor, B., & Chou, S. (2021). First-to-second antibiotic delay and hospital mortality among emergency department patients with suspected sepsis. The American Journal of Emergency Medicine, 46, 20-22.
https://doi.org/10.1016/j.ajem.2021.02.059
16. Adhikari, B., Shrestha, L., Bajracharya, M., Aryal, N., Rajbhandari, A., Maharjan, R. K., Das, S. K., Sapkota, J., Tetteh, K. K., & Das, D. (2024). Triage practices for emergency care delivery: A qualitative study among febrile patients and healthcare workers in a tertiary care hospital in Nepal. BMC Health Services Research, 24(1).
https://doi.org/10.1186/s12913-024-10663-3
17. Abebe, W., Bacha, T., Shane, A. L., & Berkowitz, T. (2021). Triage guideline for immunocompromised children with fever in an emergency centre in Ethiopia. African Journal of Emergency Medicine, 11(1), 20-25.
https://doi.org/10.1016/j.afjem.2020.10.004
18. Thobaity, A. A. (2025). Identifying the main bottlenecks in the workflow of Saudi Arabian emergency departments (EDs). Journal of Nursing Management, 2025(1).
https://doi.org/10.1155/jonm/4239274
19. Dickerson, J. E. (2023). Clinical audit, quality improvement and data quality. Anaesthesia & Intensive Care Medicine, 24(8), 486-489.
https://doi.org/10.1016/j.mpaic.2023.05.005
20. Price, T., Tredinnick-Rowe, J., Walshe, K., Tazzyman, A., Ferguson, J., Boyd, A., Archer, J., & Bryce, M. (2020). Reviving clinical governance? A qualitative study of the impact of professional regulatory reform on clinical governance in healthcare organisations in England. Health Policy, 124(4), 446-453.
https://doi.org/10.1016/j.healthpol.2020.01.004
21. Waris, B., Butt, N. I., Afzal, A., & Khizar, I. (2025). Audit and re-audit of discharge summaries completeness: A strategy to improve patient care quality. Pakistan Journal of Medical Sciences, 41(10), 2831-2836.
https://doi.org/10.12669/pjms.41.10.12224
22. Gebhardt, G., & De Waard, L. (2024). Audit as a tool for improving obstetric care in low- and middle-income countries. Best Practice & Research Clinical Obstetrics & Gynaecology, 94, 102477.
https://doi.org/10.1016/j.bpobgyn.2024.102477
23. Schlaeffer-Yosef, T., Shafat, T., Dreiher, J., Cohen, L., Codish, S., Hadad, H., & Nesher, L. (2023). Beating the clock: Reduced time to first antibiotic dose administration following an audit and feedback intervention. International Journal of Antimicrobial Agents, 62(1), 106832.
https://doi.org/10.1016/j.ijantimicag.2023.106832
24. Cherian, J., Segal, J., Sharma, R., Zhang, A., Bass, E., & Rosen, M. (2024). Patient safety practices focused on sepsis prediction and recognition.
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