Frequency and Risk Factors of Wound Dehiscence in Patients Undergoing Emergency Midline Laparotomy at Tertiary Care Hospital, Karachi
DOI:
https://doi.org/10.70749/ijbr.v3i6.3064Keywords:
Wound Dehiscence; Emergency Laparotomy; Midline Incision; Postoperative Complications; Surgical Site Infection; Risk Factors; Abdominal Surgery; ASA Classification.Abstract
Background: Wound dehiscence remains a significant postoperative challenge, particularly following emergency abdominal surgery, where time for preoperative optimization is limited. This study assessed the frequency of wound dehiscence and explored potential contributing factors in patients undergoing emergency midline laparotomy at a tertiary care hospital in Karachi. Methods: We carried out a cross-sectional study over a period of three month from 1st March 2025 to 31 May 2025 in the Department of Surgery at Jinnah Postgraduate Medical Centre (JPMC), Karachi, using non-probability consecutive sampling. We enrolled 175 patients aged 30 to 80 years who underwent emergency midline laparotomy and had an ASA physical status of I or II. We excluded patients with major comorbidities, malignancies, re-operations, or gynecological procedures. We recorded demographic, clinical, and intraoperative variables and assessed the occurrence of wound dehiscence. Associations between these variables and wound dehiscence were analyzed using chi-square tests. Results: Among 175 patients, 10 (5.7%) developed wound dehiscence. We found no statistically significant association between wound dehiscence and any of the measured variables, including age, sex, ASA classification, duration of surgery, anemia, smoking status, obesity, wound infection, or postoperative ileus (p > 0.05 across all variables). Conclusion: Wound dehiscence occurred in a small proportion of patients undergoing emergency midline laparotomy, and no single demographic or perioperative factor appeared to predict its occurrence. These findings reinforce the multifactorial nature of wound dehiscence and highlight the need for comprehensive perioperative management. Larger prospective studies incorporating nutritional and biochemical markers may help identify at-risk patients more accurately and inform preventive strategies.
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References
1. Crum, N. F. (2003). Current trends in typhoid fever. Current Gastroenterology Reports, 5(4), 279-286.
https://doi.org/10.1007/s11894-003-0064-0
2. Afzal, S., & Bashir, M. M. (2008). Determinants of wound dehiscence in abdominal surgery in public sector hospital. Annals of King Edward Medical University, 14(3), 119-119.
https://doi.org/10.21649/akemu.v14i3.46
3. Talukdar, M., Gopalarathnam, S., Paul, R., & Rahim Shaan, A. (2016). Clinical study on factors influencing wound dehiscence in emergency exploratory laparotomy. Journal of Evolution of Medical and Dental Sciences, 5(34), 1934-1938.
https://doi.org/10.14260/jemds/2016/457
4. Hegazy, T., & Soliman, S. (2020). Abdominal wall dehiscence in emergency midline laparotomy: Incidence and risk factors. The Egyptian Journal of Surgery, 39(2), 489.
https://doi.org/10.4103/ejs.ejs_7_20
5. Hanif, M., Ijaz, A., Niazi, U. F., Akhtar, I., Zaidi, A. A., & Mussadiq, M. (2001). Acute wound failure in emergency and elective laparotomies. JOURNAL-COLLEGE OF PHYSICIANS AND SURGEONS OF PAKISTAN, 11, 23-26.
6. Jones, V., Bale, S., & Harding, K. (2003). Acute and chronic wound healing. Baranoski, S. & Ayello, EA (Eds.), Wound Care Essentials: Practice Principles, 72-73.
7. Mäkelä, J. T., Kiviniemi, H., Juvonen, T., & Laitinen, S. (1995). Factors influencing wound dehiscence after midline laparotomy. The American Journal of Surgery, 170(4), 387-390.
https://doi.org/10.1016/s0002-9610(99)80309-2
8. Webster, C., Neumayer, L., Smout, R., Horn, S., Daley, J., Henderson, W., & Khuri, S. (2003). Prognostic models of abdominal wound dehiscence after laparotomy. Journal of Surgical Research, 109(2), 130-137.
https://doi.org/10.1016/s0022-4804(02)00097-5
9. Muneiah, N. S., Kumar, N. M., Sabitha, P., & Prakash, D. G. (2015). Abdominal wound dehiscence-a look into the risk factors. IOSR J Dent Med Sci, 14(1), 47-54.
10. Hurd, W. W., Bude, R. O., DeLancey, J. O., & Newman, J. S. (1994). The location of abdominal wall blood vessels in relationship to abdominal landmarks apparent at laparoscopy. American Journal of Obstetrics and Gynecology, 171(3), 642-646.
https://doi.org/10.1016/0002-9378(94)90076-0
11. Sibbald, R. G., Ostrow, B., Lowe, J., Ayello, E. A., Alavi, A., Botros, M., ... & Smart, H. (2012). Screening for the high-risk diabetic foot: a 60-second tool (2012)©: diabetes. Wound Healing Southern Africa, 5(2), 72-82.
https://hdl.handle.net/10520/EJC129079
12. Wagner, A., Huck, G., Stiehl, D., Jelkmann, W., & Hellwig-Bürgel, T. (2008). Dexamethasone impairs hypoxia-inducible factor-1 function. Biochemical and Biophysical Research Communications, 372(2), 336-340.
https://doi.org/10.1016/j.bbrc.2008.05.061
13. Hong, W. X., Hu, M. S., Esquivel, M., Liang, G. Y., Rennert, R. C., McArdle, A., Paik, K. J., Duscher, D., Gurtner, G. C., Lorenz, H. P., & Longaker, M. T. (2014). The role of hypoxia-inducible factor in wound healing. Advances in Wound Care, 3(5), 390-399.
https://doi.org/10.1089/wound.2013.0520
14. Waqar, S. H., Malik, Z. I., Razzaq, A., Abdullah, M. T., Shaima, A., & Zahid, M. A. (2005). Frequency and risk factors for wound dehiscence/burst abdomen in midline laparotomies. Journal of Ayub Medical College Abbottabad, 17(4).
https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/4203
15. Waqar, S. H., Malik, Z. I., Razzaq, A., Abdullah, M. T., Shaima, A., & Zahid, M. A. (2005). Frequency and risk factors for wound dehiscence/burst abdomen in midline laparotomies. Journal of Ayub Medical College Abbottabad, 17(4).
https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/4203
16. Naeem, M., Khattak, I. A., Samad, A., & Waheed, R. (2017). Burst abdomen: A common surgical problem. Journal of Medical Sciences, 25(2), 213-217.
https://jmedsci.com/index.php/Jmedsci/article/view/53
17. Hegazy, T. O., & Soliman, S. S. (2020). Abdominal wall dehiscence in emergency midline laparotomy: incidence and risk factors. The Egyptian Journal of Surgery, 39(2).
https://ejsur.journals.ekb.eg/article_364594.html
18. Junaid, F., Usama, M., Anwar, F., Khan, S., ur Rahman, F., & Asad, S. (2022). Sociodemographic and operative factors associated with abdominal wound dehiscence in midline laparotomies. The Professional Medical Journal, 29(10), 1448-1453.
https://www.theprofesional.com/index.php/tpmj/article/view/6710
19. SHABBIR, G., AMER, M. S., & RASHID, M. U. (2011). Skin closure in laparotomy. The Professional Medical Journal, 18(04), 552-556.
https://doi.org/10.29309/tpmj/2011.18.04.2574
20. SIRAJ, A., GILANI, A. A., DAR, M. F., & Raziq, S. (2011). Elective midline laparotomy. The Professional Medical Journal, 18(01), 106-111.
https://doi.org/10.29309/tpmj/2011.18.01.1869
21. Soomro AG, Siddiqui FG, Agha AH, et al. Selective nasogastric decompression after elective laparotomy. J Liaquat Univ Med Health Sci. 2008;7(3):177–179.
https://doi.org/10.22442/jlumhs.08720171
22. KHAN, T. A., AWAN, S. H., KHAN, S. A., & Amin, S. (2013). An audit of laparotomies;. The Professional Medical Journal, 20(02), 279-283.
https://doi.org/10.29309/tpmj/2013.20.02.686
23. Kenig, J., Richter, P., Lasek, A., Zbierska, K., & Zurawska, S. (2014). The efficacy of risk scores for predicting abdominal wound dehiscence: A case-controlled validation study. BMC Surgery, 14(1).
https://doi.org/10.1186/1471-2482-14-65
24. Col C, Soran A, Col M. Can post-abdominal wound dehiscence be predicted? Tokai J Exp Clin Med. 1998;23(3):123–127.
25. Riou, J. A., Cohen, J. R., & Johnson, H. (1992). Factors influencing wound dehiscence. The American Journal of Surgery, 163(3), 324-330.
https://doi.org/10.1016/0002-9610(92)90014-i
26. Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern epidemiology (Vol. 3). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins.
27. Muneiah, N. S., Kumar, N. M., Sabitha, P., & Prakash, D. G. (2015). Abdominal wound dehiscence-a look into the risk factors. IOSR J Dent Med Sci, 14(1), 47-54.
28. Windsor, J. A., Knight, G. S., & Hill, G. L. (1988). Wound healing response in surgical patients: Recent food intake is more important than nutritional status. Journal of British Surgery, 75(2), 135-137.
https://doi.org/10.1002/bjs.1800750215
29. Kapoor, K. K. (2017). A Clinical Study of Abdominal Wound Dehiscence with Emphasis on Surgical Management at a Tertiary Care Hospital (Master's thesis, Rajiv Gandhi University of Health Sciences (India)).
30. Van Ramshorst, G. H., Nieuwenhuizen, J., Hop, W. C., Arends, P., Boom, J., Jeekel, J., & Lange, J. F. (2009). Abdominal wound dehiscence in adults: Development and validation of a risk model. World Journal of Surgery, 34(1), 20-27.
https://doi.org/10.1007/s00268-009-0277-y
31. Talati, J., Drago, P., Ali, Z., & Hasan, N. (1987). Low cost nutritional assessment of surgical patients in Third World countries. Journal of the Pakistan Medical Association, 37(4), 86-89.
32. Henriksen, N. A., Deerenberg, E. B., Venclauskas, L., Fortelny, R. H., Miserez, M., & Muysoms, F. E. (2018). Meta‐analysis on materials and techniques for laparotomy closure: The MATCH review. World Journal of Surgery, 42(6), 1666-1678.
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