Factors of Complicated Measles in Children Less Than 5 Years of Age

Bibi Tayyaba Swati; Saima Bibi; Jaweria Bibi; Aleena Anees; Alvina Butt

doi:10.70749/ijbr.v3i3.600

Authors

Bibi Tayyaba Swati Ayub Teaching Hospital, Abbottabad, KP, Pakistan.
Saima Bibi Ayub Teaching Hospital, Abbottabad, KP, Pakistan.
Jaweria Bibi Ayub Teaching Hospital, Abbottabad, KP, Pakistan.
Aleena Anees Ayub Teaching Hospital, Abbottabad, KP, Pakistan.
Alvina Butt Ayub Teaching Hospital, Abbottabad, KP, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i3.600

Keywords:

Complicated Measles, Malnutrition, Non-vaccination, Socioeconomic Status

Abstract

Background: Complicated measles remains a significant health concern in children, with various factors contributing to its severity. Identifying the predisposing factors such as malnutrition, non-vaccination, and poor socioeconomic status is critical for improving outcomes, especially in resource-limited areas. Objective: To determine the frequency of factors leading to complicated measles in children less than 5 years of age. Study Design: Cross-sectional study. Duration and Place of Study: The study was conducted from July 2024 to January 2025 in the Department of Pediatrics at Ayub Teaching Hospital, Abbottabad. Methodology: A total of 194 children, aged 1 month to 5 years, diagnosed with complicated measles, were included in the study. Demographic information, including age, gender, residential status, parental education, and socioeconomic status, was collected. The study assessed malnutrition using WHO growth standards and vaccination status via parental reports. Results: The study included 194 children with a mean age of 3.43 ± 1.46 years and a mean weight of 12.41 ± 4.96 kg. The sample comprised 57.7% males and 42.3% females, with equal representation from rural and urban areas. The study found that 45.9% of children were malnourished, 59.3% were non-vaccinated, and 67.5% had poor socioeconomic status. Conclusion: Our study confirmed malnutrition, lack of vaccination, and poor socioeconomic status as key factors for complicated measles in children, aligning with global research. Targeted interventions in nutrition, vaccination, and healthcare access, especially in rural and underprivileged areas, are crucial to reducing disease burden and complications through effective public health initiatives.

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References

Lanke, R., & Chimurkar, V. (2024). Measles outbreak in socioeconomically diverse sections: A review. Cureus. https://doi.org/10.7759/cureus.62879

Wang, R., Jing, W., Liu, M., & Liu, J. (2022). Trends of the global, regional, and national incidence of measles, vaccine coverage, and risk factors in 204 countries from 1990 to 2019. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.798031

Morales, F., Montserrat-de la Paz, S., Leon, M. J., & Rivero-Pino, F. (2023). Effects of malnutrition on the immune system and infection and the role of nutritional strategies regarding improvements in children’s health status: A literature review. Nutrients, 16(1), 1. https://doi.org/10.3390/nu16010001

Sbarra, A. N., Jit, M., Mosser, J. F., Ferrari, M., Cutts, F., Papania, M., Kretsinger, K., McCarthy, K. A., Thakkar, N., Gaythorpe, K. A., Gamage, D., Krause, L. K., Dansereau, E., Crowcroft, N., & Portnoy, A. (2023). Population-level risk factors related to measles case fatality: A conceptual framework based on expert consultation and literature review. Vaccines, 11(8), 1389. https://doi.org/10.3390/vaccines11081389

Amimo, J. O., Michael, H., Chepngeno, J., Raev, S. A., Saif, L. J., & Vlasova, A. N. (2022). Immune impairment associated with vitamin A deficiency: Insights from clinical studies and animal model research. Nutrients, 14(23), 5038. https://doi.org/10.3390/nu14235038

Imdad, A., Mayo-Wilson, E., Haykal, M. R., Regan, A., Sidhu, J., Smith, A., & Bhutta, Z. A. (2022). Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database of Systematic Reviews, 2022(3). https://doi.org/10.1002/14651858.cd008524.pub4

Abdilahi, M. M., Mohamed, A. I., Jonah, K. M., & Ismail, A. S. (2023). Prevalence and factors associated with immunization coverage among children under five years in Mohamed Mooge health center, Hargeisa, Somaliland: A cross-sectional study. BMC Pediatrics, 23(1). https://doi.org/10.1186/s12887-023-04371-w

Fappani, C., Gori, M., Canuti, M., Terraneo, M., Colzani, D., Tanzi, E., Amendola, A., & Bianchi, S. (2022). Breakthrough infections: A challenge towards measles elimination? Microorganisms, 10(8), 1567. https://doi.org/10.3390/microorganisms10081567

Misin, A., Antonello, R. M., Di Bella, S., Campisciano, G., Zanotta, N., Giacobbe, D. R., Comar, M., & Luzzati, R. (2020). Measles: An overview of a re-emerging disease in children and Immunocompromised patients. Microorganisms, 8(2), 276. https://doi.org/10.3390/microorganisms8020276

Crowcroft, N. S., Minta, A. A., Bolotin, S., Cernuschi, T., Ariyarajah, A., Antoni, S., Mulders, M. N., Bose, A. S., & O’Connor, P. M. (2024). The problem with delaying measles elimination. Vaccines, 12(7), 813. https://doi.org/10.3390/vaccines12070813

Dhalaria, P., Kumar, P., Verma, A., Priyadarshini, P., Kumar Singh, A., Tripathi, B., & Taneja, G. (2024). Exploring landscape of measles vaccination coverage: A step towards measles elimination goal in India. Vaccine, 42(17), 3637-3646. https://doi.org/10.1016/j.vaccine.2024.04.075

Ahmad, S. H. A. K. E. E. L., Ahmad, M., & Khosa, S. H. (2014). Risk factors associated with complicated measles in children. Pakistan Journal of Medical and Health Sciences, 8(2), 469-471.

Siddiqui, F., Salam, R. A., Lassi, Z. S., & Das, J. K. (2020). The intertwined relationship between malnutrition and poverty. Frontiers in Public Health, 8. https://doi.org/10.3389/fpubh.2020.00453

Gautam, N., Dessie, G., Rahman, M. M., & Khanam, R. (2023). Socioeconomic status and health behavior in children and adolescents: A systematic literature review. Frontiers in Public Health, 11. https://doi.org/10.3389/fpubh.2023.1228632

Afzal, S., & Bint-e-Afzal, B. (2014). Risk factors associated with the outbreak of measles in Lahore, Pakistan. Annals of King Edward Medical University, 20(4), 302-302. https://doi.org/10.21649/akemu.v20i4.678

Zahidie, A., Wasim, S., & Fatmi, Z. (2014). Vaccine effectiveness and risk factors associated with measles among children presenting to the hospitals of Karachi, Pakistan. Journal of the College of Physicians and Surgeons Pakistan, 24(12), 882. https://ecommons.aku.edu/pakistan_fhs_mc_chs_chs/238/

Hao, L., Ma, C., Wannemuehler, K. A., Su, Q., An, Z., Cairns, L., Quick, L., Rodewald, L., Liu, Y., He, H., Xu, Q., Ma, Y., Yu, W., Zhang, N., Li, L., Wang, N., Luo, H., Wang, H., & Gregory, C. J. (2016). Risk factors for measles in children aged 8 months–14 years in China after nationwide measles campaign: A multi-site case-control study, 2012–2013. Vaccine, 34(51), 6545-6552. https://doi.org/10.1016/j.vaccine.2016.02.005

Mayxay, M., Khomthilat, T., Souvannasing, P., Phounesavath, K., Vorasane, B., Keomany, S., Douangdala, P., Philavong, K., Srour, L., & Newton, P. N. (2007). Factors associated with a measles outbreak in children admitted at Mahosot hospital, Vientiane, Laos. BMC Public Health, 7(1). https://doi.org/10.1186/1471-2458-7-193