Role of Zinc as Adjuvant Therapy in the Management of Pneumonia in Children of Age 2 Years to 5 Years

Authors

  • Anam Naz Department of Paediatrics, Islamabad Medical Complex, NESCOM Hospital, Islamabad, Pakistan.
  • Sidra Gul Department of Paediatrics, Islamabad Medical Complex, NESCOM Hospital, Islamabad, Pakistan.
  • Wardah Zahoor Department of Paediatrics, Islamabad Medical Complex, NESCOM Hospital, Islamabad, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i3.794

Keywords:

Zinc Supplantation, Pneumonia, Time of Recovery

Abstract

Objective: To evaluate the mean recovery time in pediatric pneumonia patients receiving zinc as an adjunct to standard treatment compared to those who do not receive zinc supplementation. Methods: This randomized clinical trial was conducted in pediatric unit of Islamabad Medical Complex Hospital, NESCOM Islamabad from January 2024 to July 2024. A total of 110 children of age 2-5 years admitted with pneumonia were included. In group Z; 15 mg Zinc twice daily was given as an adjuvant to standard treatment till the hospital stay of patient in the hospital or up-to 7 days after starting the treatment.  In group C; only standard treatment of pneumonia was given. Time of recovery from pneumonia was the primary study outcome. Results: The mean age of participants was 3.32 ± 0.9 years in group Z and 3.55 ± 0.83 years in group C, with a p-value of 0.17. In terms of gender distribution, group Z comprised 34 female patients (61.8%), compared to 27 female patients (49.1%) in group C (p-value 0.25). Mean time of recovery was significantly lower in group Z in comparison to group C patients with mean recovery time of 32.27±6.38 hours in group Z and 52.61±6.96 hours in group C (p-value <0.0001). Conclusion: Zinc supplantation has a significant beneficial effect in enhancing recovery from pneumonia symptoms in hospitalized children. So, zinc supplementation can be added to the standard treatment regimen of pneumonia treatment.

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References

Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: an analysis for the Global Burden of Disease Study 2017. The Lancet Infectious diseases. 2020;20(1):60-79. https://doi.org/10.1016/s1473-3099(19)30557-2

Mathew JL. Etiology of Childhood Pneumonia: What We Know, and What We Need to Know! : Based on 5th Dr. IC Verma Excellence Oration Award. Indian journal of pediatrics. 2018;85(1):25-34. https://doi.org/10.1007/s12098-017-2486-y

Agweyu A, Lilford RJ, English M. Appropriateness of clinical severity classification of new WHO childhood pneumonia guidance: a multi-hospital, retrospective, cohort study. The Lancet Global health. 2018;6(1):e74-e83. https://doi.org/10.1016/s2214-109x(17)30448-5

Nascimento-Carvalho AC, Nascimento-Carvalho CM. Clinical management of community-acquired pneumonia in young children. Expert opinion on pharmacotherapy. 2019;20(4):435-42. https://doi.org/10.1080/14656566.2018.1552257

Oliwa JN, Marais BJ. Vaccines to prevent pneumonia in children - a developing country perspective. Paediatric respiratory reviews. 2017;22:23-30. https://doi.org/10.1016/j.prrv.2015.08.004

Nguyen TK, Tran TH, Roberts CL, Fox GJ, Graham SM, Marais BJ. Risk factors for child pneumonia - focus on the Western Pacific Region. Paediatric respiratory reviews. 2017;21:95-101. https://doi.org/10.1016/j.prrv.2016.07.002

Imdad A, Rogner J, Sherwani RN, Sidhu J, Regan A, Haykal MR, et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years. The Cochrane database of systematic reviews. 2023;3(3):Cd009384. https://doi.org/10.1002/14651858.cd009384.pub3

La QP, Le SH, Nguyen PM, Tran LC. Zinc Deficiency and the Severity of Pneumonia in Vietnamese Children: A Hospital-Based Study. Cureus. 2024;16(7):e65771. https://doi.org/10.7759/cureus.65771

Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020;12(1). https://doi.org/10.3390/nu12010236

Gupta S, Brazier AKM, Lowe NM. Zinc deficiency in low- and middle-income countries: prevalence and approaches for mitigation. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 2020;33(5):624-43. https://doi.org/10.1111/jhn.12791

Rerksuppaphol L, Rerksuppaphol S. Efficacy of Adjunctive Zinc in Improving the Treatment Outcomes in Hospitalized Children with Pneumonia: A Randomized Controlled Trial. Journal of tropical pediatrics. 2020;66(4):419-27. https://doi.org/10.1093/tropej/fmz082

Brooks WA, Yunus M, Santosham M, Wahed MA, Nahar K, Yeasmin S, et al. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet (London, England). 2004;363(9422):1683-8. https://doi.org/10.1016/s0140-6736(04)16252-1

Qasemzadeh MJ, Fathi M, Tashvighi M, Gharehbeglou M, Yadollah-Damavandi S, Parsa Y, et al. The effect of adjuvant zinc therapy on recovery from pneumonia in hospitalized children: a double-blind randomized controlled trial. Scientifica. 2014;2014:694193. https://doi.org/10.1155/2014/694193

Wadhwa N, Chandran A, Aneja S, Lodha R, Kabra SK, Chaturvedi MK, et al. Efficacy of zinc given as an adjunct in the treatment of severe and very severe pneumonia in hospitalized children 2-24 mo of age: a randomized, double-blind, placebo-controlled trial. The American journal of clinical nutrition. 2013;97(6):1387-94. https://doi.org/10.3945/ajcn.112.052951

Howie S, Bottomley C, Chimah O, Ideh R, Ebruke B, Okomo U, et al. Zinc as an adjunct therapy in the management of severe pneumonia among Gambian children: randomized controlled trial. Journal of global health. 2018;8(1):010418. https://doi.org/10.7189/jogh.08.010418

Sempértegui F, Estrella B, Rodríguez O, Gómez D, Cabezas M, Salgado G, et al. Zinc as an adjunct to the treatment of severe pneumonia in Ecuadorian children: a randomized controlled trial. The American journal of clinical nutrition. 2014;99(3):497-505. https://doi.org/10.3945/ajcn.113.067892

Srinivasan MG, Ndeezi G, Mboijana CK, Kiguli S, Bimenya GS, Nankabirwa V, et al. Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial. BMC medicine. 2012;10:14. https://doi.org/10.1186/1741-7015-10-14

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Published

2025-03-19

How to Cite

Naz, A., Gul, S., & Zahoor, W. (2025). Role of Zinc as Adjuvant Therapy in the Management of Pneumonia in Children of Age 2 Years to 5 Years. Indus Journal of Bioscience Research, 3(3), 293-296. https://doi.org/10.70749/ijbr.v3i3.794