Thyroid Dysfunction and Its Relationship with Abnormal Uterine Bleeding in Females

Asawir Adan Asawir Adan; Abdul Ali Khan; Muhammad Adil Abid; Mahnoor Shoukat; Atiqa Noor; Maryam Khalid; Sadaf Khan

doi:10.70749/ijbr.v3i3.836

Authors

Asawir Adan Mustafa Riphah International University, Islamabad, Pakistan.
Abdul Ali Khan University of New Mexico, United States.
Muhammad Adil Abid Northwest Institute of Health Sciences, Peshawar, Pakistan.
Mahnoor Shoukat Nishtar Medical University, Multan, Pakistan.
Atiqa Noor King Edward Medical University, Lahore, Pakistan.
Maryam Khalid Isra University, Islamabad, Pakistan.
Sadaf Khan Nishtar Medical University, Multan, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i3.836

Keywords:

Thyroid Profile, AUB, Thyroid dysfunction, Menstrual Disturbances

Abstract

Background: Abnormal uterine bleeding is regarded as a serious and complicated issue. Thyroid hormones play significant role in the reproductive function of women. Both Hypothyroidism and hyperthyroidism may result in menstrual disturbances. Objective: Present study was conducted to assess the prevalence of thyroid disorders in dysfunctional uterine bleeding patients. Methodology: Hospital based Cross sectional study is conducted in Gynecology Department of different hospitals and clinics of Rawalpindi and Islamabad. Study period is 4 months after the approval of the research board. 200 patients were analyzed for the entire duration of 4 months (from September 2024 to December 2024) of research. Simple Random Sampling technique was used, and analyzed using SPSS version 25. Results: Most of the AUB cases were in the age group of 25-29 years, (26%). Thyroid disorders were prevalent in 33% of the women studied. Hypothyroidism was present in 26% and Hyperthyroidism in 6.7% of the women with AUB. The most common menstrual pattern was oligomenorrhea which was present in 62.8 % of the AUB cases. Pelvic ultrasound (USG) revealed on-structural causes were the most common (48.5%) while structural causes were the least common (7.1%). Conclusion: Thyroid dysfunction is associated with menstrual disturbances (abnormal uterine bleeding). Prevalence of hypothyroidism was more common than hyperthyroidism in AUB cases. Thyroid function tests should be performed in all patients with menstrual irregularities (AUB) to avoid unnecessary interventions.

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References

Menon S, College GM. International Journal of Scientific Research Prevalence of Thyroid Abnormality in Perimenopausal Women Obstetrics & Gynaecology. 2023;(2277):12– 4. https://doi.org/10.36106/ijsr/6006818

Choudhury SA, Nath P. Abnormal uterine bleeding; its prevalence, causes and management in a tertiary care hospital. New Indian J OBGYN. 2020;7(1):52–7. https://doi.org/10.21276/obgyn.2020.7.11

Whitaker L, Critchley HOD. Abnormal uterine bleeding. Best Pract Res Clin Obstet Gynaecol [Internet]. 2016;34:54–65. Available from: http://doi.org/10.1016/j.bpobgyn.2015.11.012

Sabre A, Serventi L, Nuritdinova D, Schiattarella A, Sisti G. Abnormal uterine bleeding types according to the palm-coein figo classification in a medically underserved american community. J Turkish Ger Gynecol Assoc. 2021;22(2):91–6. https://doi.org/10.4274/jtgga.galenos.2021.2020.0228

Jain V, Chodankar RR, Maybin JA, Critchley HOD. Uterine bleeding: how understanding endometrial physiology underpins menstrual health. Nat Rev Endocrinol. 2022;18(5):290–308. https://doi.org/10.1038/s41574-021-00629-4

Sahu HD, Varma A V, Karmarkar S, Malukani K, Khanuja A, Kesharwani P. Endometrial Histopathology in Abnormal Uterine Bleeding and Its Relation with Thyroid Profile and Endometrial Thickness. Cureus. 2023;15(4):12–8. https://doi.org/10.7759/cureus.37931

V. S, Gopalan U. Clinical pattern and presentation of abnormal uterine bleeding. Int J Reprod Contraception, Obstet Gynecol. 2019;9(1):126. https://doi.org/10.18203/2320-1770.ijrcog20195587

Munro MG, Critchley HOD, Broder MS, Fraser IS. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynecol Obstet. 2011;113(1):3–13. https://doi.org/10.1016/j.ijgo.2010.11.011

Leal CRV, Vannuccini S, Jain V, Dolmans M-M, Di Spiezio Sardo A, Al- Hendy A, et al. Abnormal uterine bleeding: The well-known and the hidden face. J Endometr Uterine Disord. 2024;6(April):100071. https://doi.org/10.1016/j.jeud.2024.100071

Kitahara Y, Hiraike O, Ishikawa H, Kugu K, Takai Y, Yoshino O, et al. National survey of abnormal uterine bleeding according to the FIGO classification in Japan. J Obstet Gynaecol Res. 2023;49(1):321–30. https://doi.org/10.1111/jog.15464

Viganò S, Smedile A, Cazzella C, Marra P, Bonaffini PA, Sironi S. Abnormal Uterine Bleeding: A Pictorial Review on Differential Diagnosis and Not-So- Common Cases of Interventional Radiology Management. Diagnostics. 2024;14(8). https://doi.org/10.3390/diagnostics14080798

Yuksel S, Tuna G, Celik HG, Salman S. Endometrial polyps: Is the prediction of spontaneous regression possible? Obstet Gynecol Sci. 2021;64(1):114–21. https://doi.org/10.5468/ogs.20242

MacGregor B, Munro MG, Lumsden MA. Therapeutic options for the management of abnormal uterine bleeding. Int J Gynecol Obstet. 2023;162(S2):43–57. https://doi.org/10.1002/ijgo.14947

Lonky NM, Chiu V, Portugal C, Estrada EL, Chang J, Fischer H, et al. Adenomyosis in women undergoing hysterectomy for abnormal uterine bleeding associated with uterine leiomyomas. PLoS One [Internet]. 2023;18(12 December):1–14. http://doi.org/10.1371/journal.pone.0294925

Zhang HL, Zhu JE, Deng EY, Li JX, Sun LP, Peng CZ, et al. Ultrasound- guided percutaneous microwave ablation for adenomyosis with abnormal uterine bleeding: clinical outcome and associated factors. Int J Hyperth. https://doi.org/10.1080/02656736.2023.2249274