Insights into the Prevalence of Diabetes Mellitus in Dogs in Pakistan

Authors

  • Adeel Khalid Department of Clinical Medicine and Surgery, University of Agriculture Faisalabad, Pakistan.
  • Bilal Ahmad Animal Health Clinic, Bani Gala, Islamabad, Pakistan.
  • Muhammad Ahtsham Waheed Department of Clinical Medicine and Surgery, University of Agriculture Faisalabad, Pakistan.
  • Rameesha Azhar Department of Epidemiology and Public Health, University of Agriculture Faisalabad, Pakistan.
  • Khurram Ashfaq Department of Clinical Medicine and Surgery, University of Agriculture Faisalabad, Pakistan.
  • Arsalan Khan Veterinary Research & Disease Investigation Center, Dera Ismail Khan, Pakistan.
  • Hafiz Aftab Ahmed Department of Clinical Medicine and Surgery, University of Agriculture Faisalabad, Pakistan.
  • Muhammad Adan Sana Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
  • Rai Bahadur Kharl Department of Clinical Medicine and Surgery, University of Agriculture Faisalabad, Pakistan.
  • Mughees Aizaz Alvi Department of Clinical Medicine and Surgery, University of Agriculture Faisalabad, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i3.838

Keywords:

Canine, Diabetes Mellitus, Prevalence, Fasting Blood Glucose, LFT’s

Abstract

Diabetes mellitus is a condition that affects dogs and is caused by inadequate insulin production or action. The disorder is influenced by genetics, the immune system, and lifestyle exposures such as obesity and medication use. Dogs typically experience Type 1 diabetes and require exogenous insulin for life. The disorder is prevalent in middle-aged to older dogs, and the incidence rate among female dogs is increasing. Dogs with diabetes require insulin treatment and regular monitoring to ensure proper dosage. Various monitoring tools are available to veterinarians for effective management. This study aims to investigate the prevalence of diabetes mellitus in dogs in District Faisalabad and Islamabad Capital Territory of Pakistan. A total of 180 samples were collected, fasting blood glucose levels were measured using a commercial glucose meter and were more in females (127.78 mg/dl) than males (96.4 mg/dl). The overall prevalence for the 43 positive dogs examined were 23.88% with 95% confidence interval (CI) limits 18.25-30.62. Female dogs were more prevalent (42.30%) than male dogs (9.80%). On the basis of age, diabetes mellitus was more in dogs with age > 2 years (29.23%) and less in dogs with age < 6 months (10.34%). Neutered female dogs were at high risk (35.93%) as compared to neutered male dogs (11.68%) while intact male dogs were at much higher risk (28.20%) than neuter male dogs but intact female dogs were considerably less at risk than neuter females. Laboratory analysis was carried out to evaluate the other markers related to diabetes which includes urinalysis, liver functioning tests, CBC and serum biochemistry. The mean values of ALT and ALP were more in females (92.95 & 264.83) than males (62.24 & 239.02). This study followed the recommendations of the Recognized Animal Ethics Committee, University of Agriculture, Faisalabad. The outcomes of this research give valuable evidence on the prevalence of diabetes in dogs in Pakistan and will help raise awareness about this disease among pet owners.

Downloads

Download data is not yet available.

References

Afzal, S., M. Nasir, M.N. Bhaya, K. Junaid, A. Arshad, M.Z. Raza, M.A. Ali, W. Ahmad and S. Yasobant, 2022. Multifactorial complexity and zoonotic aspects of dog-mediated human rabies in Pakistan. Pakistan Veterinary Journal, 42:445-452. https://doi.org/10.29261/pakvetj/2022.081

Ahmed, I., 2006. B. Goldstein B,“Diabetes mellitus,” Dermatol. Clin., 24:237-246. https://doi.org/10.1016/j.clindermatol.2006.04.009

Alvarez, M.S., V. Herrería-Bustillo, A.F. Utset and J. Martínez, 2015. Juvenile Diabetes Mellitus and Concurrent Exocrine Pancreatic Insufficiency in a Labrador Retriever: Long-Term Management. J. Am. Anim. Hosp. Assoc., 51.

Association, A.D., 2010. Diagnosis and classification of diabetes mellitus. Diabetes. Care, 33:62-69.

Behrend, E., A. Holford, P. Lathan, R. Rucinsky and R. Schulman, 2018. 2018 AAHA diabetes management guidelines for dogs and cats. J. Am. Anim. Hosp. Assoc., 54:1-21. https://doi.org/10.5326/jaaha-ms-6822

Bland, I., A. Guthrie-Jones, R. Taylor and J. Hill, 2009. Dog obesity: owner attitudes and behaviour. Prev. Vet. Med., 92:333-340.

Blois, S.L., E. Dickie, S.A. Kruth and D.G. Allen, 2011. Multiple endocrine diseases in dogs: 35 cases (1996–2009). J. Am. Vet. Med. Assoc., 238:1616-1621.

Cai, S.V., T.R. Famula, A.M. Oberbauer and R.S. Hess, 2019. Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs. J. Vet. Intern., 33:1926-1934. https://doi.org/10.1111/jvim.15570

Caney, S.M., 2013. Pancreatitis and diabetes in cats. Vet. Clin. North. Am. Small. Anim., 43:303-317.

Catchpole, B., J. Ristic, L. Fleeman and L. Davison, 2005. Canine diabetes mellitus: can old dogs teach us new tricks? Diabetol, 48:1948-1956.

Catchpole, B., J.P. Adams, A.L. Holder, A.D. Short, W.E. Ollier and L.J. Kennedy, 2013. Genetics of canine diabetes mellitus: are the diabetes susceptibility genes identified in humans involved in breed susceptibility to diabetes mellitus in dogs? Vet. J., 195:139-147. https://doi.org/10.1016/j.tvjl.2012.11.013

Catchpole, B., L. Kennedy, L. Davison and W. Ollier, 2008. Canine diabetes mellitus: from phenotype to genotype. J. Small. Anim. Pract., 49:4-10.

Cohen, T.A., R.W. Nelson, P.H. Kass, M.M. Christopher and E.C. Feldman, 2009. Evaluation of six portable blood glucose meters for measuring blood glucose concentration in dogs. J. Am. Vet. Med. Assoc., 235:276-280.

Cook, A.K. and D.E.-C. Dip. ACVIM-SAIM, 2012. Monitoring methods for dogs and cats with diabetes mellitus. J. Diabetes Sci. Technol., 6:491-495. https://doi.org/10.1177/193229681200600302

Corbee, R.J., 2013. Obesity in show dogs. J. Anim. Physiol. Anim. Nutr., 97:904-910.

Corradini, S., B. Pilosio, F. Dondi, G. Linari, S. Testa, F. Brugnoli, P. Gianella, M. Pietra and F. Fracassi, 2016. Accuracy of a flash glucose monitoring system in diabetic dogs. J. Vet. Intern., 30:983-988.

Courcier, E., R. Thomson, D. Mellor and P. Yam, 2010. An epidemiological study of environmental factors associated with canine obesity. J. Small. Anim. Pract., 51:362-367. https://doi.org/10.1111/j.1748-5827.2010.00933.x

Das, S. and C. Lodh, 2015. Epidemiology of canine diabetes mellitus in West Bengal. Indian J. Canine. Pract., 7.

Davison, L., M. Herrtage and B. Catchpole, 2005. Study of 253 dogs in the United Kingdom with diabetes mellitus. Vet. Rec., 156:467-471.

Domori, A., A. Sunahara, M. Tateno, T.S. Miyama, A. Setoguchi and Y. Endo, 2014. The clinical utility of two human portable blood glucose meters in canine and feline practice. Vet. Clin. Pathol., 43:55-62. https://doi.org/10.1111/vcp.12115

Durocher, L.L., K.W. Hinchcliff, S.P. DiBartola and S.E. Johnson, 2008. Acid-base and hormonal abnormalities in dogs with naturally occurring diabetes mellitus. J. Am. Vet. Med. Assoc., 232:1310-1320.

Ettinger, S.J., E.C. Feldman and E. Cote, 2016. Textbook of Veterinary Internal Medicine-Inkling E-Book. J. Res. Health. Sci.

Fall, T., H.H. Hamlin, Å. Hedhammar, O. Kämpe and A. Egenvall, 2007. Diabetes mellitus in a population of 180,000 insured dogs: incidence, survival, and breed distribution. J. Vet. Intern., 21:1209-1216.

Feldman, E., 2004. Canine diabetes mellitus. J. Endocrinol. Reprod., 486-538.

German, A.J., 2006. The growing problem of obesity in dogs and cats. Nutr. J., 136:1940S-1946S. https://doi.org/10.1093/jn/136.7.1940s

Gilor, C., S. Niessen, E. Furrow and S. DiBartola, 2016. What's in a name? Classification of diabetes mellitus in veterinary medicine and why it matters. J. Vet. Intern., 30:927-940.

Greco, D.S., 2018. Diabetes mellitus in animals: diagnosis and treatment of diabetes mellitus in dogs and cats. In: Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome. J. Res. Health. Sci., pp: 507-517.

Güngör, G.Ç.A., Ç. Gültekin, A. Kükner, İ. Etikan, M. Temizel and F.E. Özgencil, 2022. Effect of Topical Insulin and Ozonized Cream for the Treatment of Full-thickness Dermal Burn Injuries: A Clinical and Histopathological Study in Diabetic Rats. Pak. Vet. J., 42:229-235.

Guptill, L., L. Glickman and N. Glickman, 2003. Time trends and risk factors for diabetes mellitus in dogs: analysis of veterinary medical data base records (1970–1999). Vet. J., 165:240-247. https://doi.org/10.1016/s1090-0233(02)00242-3

Hassan, F., B. Aslam, F. Muhammad and M.N. Faisal, 2022. Hypoglycemic Properties of Sphaeranthus indicus and Nigella sativa in Alloxan Induced Diabetes Mellitus in Rats: A New Therapeutic Horizon. Pak. Vet. J., 42:141-146.

Heeley, A.M., D.G. O’Neill, L.J. Davison, D.B. Church, E.K. Corless and D.C. Brodbelt, 2020. Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival. Genet. Med., 7:1-19.

Herrtage, M., 2009. New strategies in the management of canine diabetes mellitus. In: Proceedings of the 34 th World Small Animal Veterinary Congress WSAVA São Paulo, Braz. J. Med. Biol. Res.

Hess, R.S., 2013. Canine diabetic emergencies. Top. Companion. Anim. Med., 201-208.

Hill, R.C., 2009. Nutritional therapies to improve health: lessons from companion animals: Conference on ‘Multidisciplinary approaches to nutritional problems’ Symposium on ‘Nutrition and health’. Br. J. Nutr., 68:98-102. https://doi.org/10.1017/s0029665108008835

Ishtiaq, S.M., J.A. Khan, F. Muhammad and M. Shahid, 2022. Peroxisome proliferator-activated receptor gamma agonists modulate high-fat diet-and carbon tetrachloride-induced non-alcoholic fatty liver disease pathophysiology and transcriptional expression of inflammatory markers in a murine model. Pakistan Veterinary Journal, 42:292-299.

Johnson, B.M., M.M. Fry, B. Flatland and C.A. Kirk, 2009. Comparison of a human portable blood glucose meter, veterinary portable blood glucose meter, and automated chemistry analyzer for measurement of blood glucose concentrations in dogs. J. Am. Vet. Med. Assoc., 235:1309-1313.

Kim, N.-Y., J. An, J.-K. Jeong, S. Ji, S.-H. Hwang, H.-S. Lee, M.-C. Kim, H.-W. Kim, S. Won and Y. Kim, 2019. Evaluation of a human glycated hemoglobin test in canine diabetes mellitus. J. Vet. Diagn. Investig., 31:408-414.

Kour, H. and S. Chhabra, 2021. Diabetes mellitus in canines: A concise review.

Kuotsu, K., N.B. Devi and N. Kuotsu, 2023. Interpretation of Liver Function Tests in Canine and Feline.

Laflamme, D.P. 2006. Understanding and managing obesity in dogs and cats. J. Small. Anim. Pract., 36:1283-1295. https://doi.org/10.1016/j.cvsm.2006.08.005

Lund, E.M., P.J. Armstrong, C.A. Kirk and J.S. Klausner, 2006. Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. Int. J. Appl. Res. Vet. Med., 4:177.

Mao, J., Z. Xia, J. Chen and J. Yu, 2013. Prevalence and risk factors for canine obesity surveyed in veterinary practices in Beijing, China. Prev. Vet. Med., 112:438-442.

Marshall, W., B. Bockstahler, D. Hulse and S. Carmichael, 2009. A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog. Vet. Comp. Orthop. Traumatol., 22:339-345.

Mattin, M., D. O'Neill, D. Church, P.D. McGreevy, P.C. Thomson and D. Brodbelt, 2014. An epidemiological study of diabetes mellitus in dogs attending first opinion practice in the UK. Vet. Rec., 174:349-349. https://doi.org/10.1136/vr.101950

McGreevy, P., P. Thomson, C. Pride, A. Fawcett, T. Grassi and B. Jones, 2005. Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved. Vet. Rec., 156:695-702.

Mori, A., H. Oda, E. Onozawa, S. Shono, T. Takahashi, S. Yamashita, H. Fujimoto and T. Sako, 2016. Evaluation of portable blood glucose meters using canine and feline pooled blood samples. Pol. J. Vet. Sci.

Nelson, R.W., 2015. Canine diabetes mellitus. Endocrine, 213-257.

Nelson, R.W. and C.E. Reusch, 2014. Animal models of disease: classification and etiology of diabetes in dogs and cats. J. Endocrinol., 222:1-9.

Newcombe, R.G., 1998. "Two-Sided Confidence Intervals for the Single Proportion: Comparison of Seven Methods". Stat. Med., 17:857-872. https://doi.org/10.1002/(sici)1097-0258(19980430)17:8%3C857::aid-sim777%3E3.0.co;2-e

Pápa, K., Á. Máthé, Z. Abonyi-Tóth, Á. Sterczer, R. Psáder, C. Hetyey, P. Vajdovich and K. Vörös, 2011. Occurrence, clinical features and outcome of canine pancreatitis (80 cases). Acta. Vet. Hung., 59:37-52.

Rand, J.S., 2020. Diabetes Mellitus in Dogs and Cats. J. Vet. Intern. Med., 93-102.

Sallander, M., M. Hagberg, Å. Hedhammar, M. Rundgren and J.E. Lindberg, 2010. Energy-intake and activity risk factors for owner-perceived obesity in a defined population of Swedish dogs. Prev. Vet. Med., 96:132-141.

Shabbir, M.Z., L.P. UVAS, A. Ahmad, M.N. Zahid, J. Nazir, M. Nawaz and H. Akbar, 2013. Sample collection guide. Sample collection guide. https://doi.org/10.5005/jp/books/14242_12

Sidhu, R.S. and S.S. Randhawa, 2019. A review on diagnosis and management of diabetes mellitus in dogs. Int. J. Curr. Microbiol. App. Sci., 8:10-16.

Sindi, R.A., S. Alam, M. Rizwan, M.I. Ullah, N. Ijaz, Z. Iqbal, R. Muzafar, R. Akram, M.W. Nazar and R. Hussain, 2023. Investigations of hemato-biochemical, histopathological, oxidative stress and reproductive effects of thiram in albino rats. Pak Vet J., 43:255-261.

Stoy, J., 2014. Mutations in the insulin gene. Curr. Diab. Rep.

Tvarijonaviciute, A., J.J. Ceron, S.L. Holden, D.J. Cuthbertson, V. Biourge, P.J. Morris and A.J. German, 2012. Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome. BMC. Vet. Res., 8:1-8. https://doi.org/10.1186/1746-6148-8-147

Wejdmark, A.K., B. Bonnett, Å. Hedhammar and T. Fall, 2011. Lifestyle risk factors for progesterone‐related diabetes mellitus in elkhounds—a case—control study. J. Small. Anim. Pract., 52:240-245.

Wubie, A. and G. Getaneh, 2015. Factors and Management of Diabetes Mellitus in Pets. Eur. J. Appl. Physiol., 7:241-249.

Yoon, S., L.M. Fleeman, B.J. Wilson, C.S. Mansfield and P. McGreevy, 2020. Epidemiological study of dogs with diabetes mellitus attending primary care veterinary clinics in Australia. Vet. Rec., 187:22-22. https://doi.org/10.1136/vr.105467

Downloads

Published

2025-03-18

How to Cite

Khalid, A., Ahmad, B., Waheed, M. A., Azhar, R., Ashfaq, K., Khan, A., Ahmed, H. A., Sana, M. A., Kharl, R. B., & Alvi, M. A. (2025). Insights into the Prevalence of Diabetes Mellitus in Dogs in Pakistan. Indus Journal of Bioscience Research, 3(3), 275-286. https://doi.org/10.70749/ijbr.v3i3.838