Diet, Dyslipidemia and Breast Cancer: Macronutrients Imbalance as Dietary Risk of Breast Cancer among the Pakhtun Women of Khyber Pakhtunkhwa, Pakistan

Authors

  • Hira Ayub Department of Food & Nutrition Sciences, College of Home Economics, University of Peshawar, KP, Pakistan.
  • Fazia Ghaffar Department of Food & Nutrition Sciences, College of Home Economics, University of Peshawar, KP, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i3.869

Keywords:

Breast Cancer, Macronutrient, Dietary Fats, Body Composition, Anthropometry, Dyslipidemia

Abstract

Breast cancer (BC) is the most prevalent cancer in women and the second foremost reason for cancer-related deaths in after lung cancer.  The current study analyzed dietary intake patterns and health indicators of 328 newly diagnosed breast cancer females of Pathan ethnicity at Peshawar district, KP Pakistan. The objectives were to analyze the dietary macronutrient intake patterns and its subsequent effects on the prevalence of dyslipidemia among these breast cancer patients.  Participants, selected from Khyber Teaching Hospital, provided data on demographics, anthropometrics and biochemical tests covered random blood glucose and lipid profile. Key findings include a predominantly married sample (98%), with 18.2% from peri-urban areas and 48.2% having laborer husbands. The majority (76.4%) lived in joint family systems with a monthly income below 30 thousand. The mean BMI was 28.368 ± 4.9890, indicating an overweight tendency. Family history revealed conditions like diabetes, hypertension, elevated blood lipids, obesity, and overweight. Blood test results indicated high cholesterol, triglycerides, HDL, and LDL, suggesting generalized body then contribution to overweight and linked to the disease or diet. This study suggests that total dietary fat and its subtypes may increase the risk of breast cancer among Pathan women. A direct association was found between fat intake and BC development. Cautious fat consumption is recommended to reduce risk. Further research is needed, and nutrition education should be prioritized, especially for Pakhtun women, to promote dietary improvements.

Downloads

Download data is not yet available.

References

Hauner, D., Janni, W., Rack, B., & Hauner, H. (2011). The effect of overweight and nutrition on prognosis in breast cancer. Deutsches Ärzteblatt international, 108(47), 795. https://doi.org/10.3238/arztebl.2011.0795

Ferrini, K. (2015). Lifestyle, nutrition and breast cancer: Facts and presumptions for consideration. ecancermedicalscience, 9. https://doi.org/10.3332/ecancer.2015.557

De Cicco, P., Catani, M. V., Gasperi, V., Sibilano, M., Quaglietta, M., & Savini, I. (2019). Nutrition and breast cancer: A literature review on prevention, treatment and recurrence. Nutrients, 11(7), 1514. https://doi.org/10.3390/nu11071514

Rock, C. L., & Demark-Wahnefried, W. (2002). Nutrition and survival after the diagnosis of breast cancer: A review of the evidence. Journal of Clinical Oncology, 20(15), 3302-3316. https://doi.org/10.1200/jco.2002.03.008

Kopin, L., & Lowenstein, C. J. (2017). Dyslipidemia. Annals of Internal Medicine, 167(11), ITC81-ITC96. https://doi.org/10.7326/aitc201712050

Tall, A. R., Thomas, D. G., Gonzalez-Cabodevilla, A. G., & Goldberg, I. J. (2022). Addressing dyslipidemic risk beyond LDL-cholesterol. Journal of Clinical Investigation, 132(1). https://doi.org/10.1172/jci148559

Van Wyk, J., & Carbonatto, C. (2016). The social functioning of women with breast cancer in the context of the life world: A social work perspective. Social Work/Maatskaplike Werk, 52(3). https://doi.org/10.15270/52-3-518

Bener, A., Ayoubi, H. R., Ali, A. I., Al-Kubaisi, A., & Al-Sulaiti, H. (2010). Does consanguinity lead to decreased incidence of breast cancer? Cancer Epidemiology, 34(4), 413-418. https://doi.org/10.1016/j.canep.2010.04.004

Xiao, Y., Zhao, N., Wang, H., Zhang, J., He, Q., Su, D., Zhao, M., Wang, L., Zhang, X., Gong, W., Hu, R., Yu, M., Ding, G., Cong, L., & Ye, Z. (2013). Association between socioeconomic status and obesity in a Chinese adult population. BMC Public Health, 13(1). https://doi.org/10.1186/1471-2458-13-355

Pacholczak, R., Klimek-Piotrowska, W., & Kuszmiersz, P. (2016). Associations of anthropometric measures on breast cancer risk in pre- and postmenopausal women—a case-control study. Journal of Physiological Anthropology, 35(1). https://doi.org/10.1186/s40101-016-0090-x

Kelly, R. K., Watling, C. Z., Tong, T. Y., Piernas, C., Carter, J. L., Papier, K., Key, T. J., & Perez-Cornago, A. (2021). Associations between macronutrients from different dietary sources and serum lipids in 24 639 UK Biobank study participants. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(7), 2190-2200. https://doi.org/10.1161/atvbaha.120.315628

Lodi, M., Kiehl, A., Qu, F. L., Gabriele, V., Tomasetto, C., & Mathelin, C. (2022). Lipid intake and breast cancer risk: Is there a link? A new focus and meta-analysis. European Journal of Breast Health, 18(2), 108-126. https://doi.org/10.4274/ejbh.galenos.2021.2021-11-2

Chajes, V., Thiebaut, A. C., Rotival, M., Gauthier, E., Maillard, V., Boutron-Ruault, M., Joulin, V., Lenoir, G. M., & Clavel-Chapelon, F. (2008). Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC study. American Journal of Epidemiology, 167(11), 1312-1320. https://doi.org/10.1093/aje/kwn069

Cowen, S., McLaughlin, S., Hobbs, G., Coad, J., Martin, K., Olfert, I., & Vona-Davis, L. (2015). High-fat, high-calorie diet enhances mammary carcinogenesis and local inflammation in MMTV-pymt mouse model of breast cancer. Cancers, 7(3), 1125-1142. https://doi.org/10.3390/cancers7030828

Cao, Y., Hou, L., & Wang, W. (2015). Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta‐analysis of prospective cohort studies. International Journal of Cancer, 138(8), 1894-1904. https://doi.org/10.1002/ijc.29938

Hunter, D. J., Spiegelman, D., Adami, H., Beeson, L., Van den Brandt, P. A., Folsom, A. R., Fraser, G. E., Goldbohm, R. A., Graham, S., Howe, G. R., Kushi, L. H., Marshall, J. R., McDermott, A., Miller, A. B., Speizer, F. E., Wolk, A., Yaun, S., & Willett, W. (1996). Cohort studies of fat intake and the risk of breast cancer — A pooled analysis. New England Journal of Medicine, 334(6), 356-361. https://doi.org/10.1056/nejm199602083340603

Boyd, N., Martin, L., Noffel, M., Lockwood, G., & Trichler, D. (1993). A meta-analysis of studies of dietary fat and breast cancer risk. British Journal of Cancer, 68(3), 627-636. https://doi.org/10.1038/bjc.1993.398

DANDAMUDI, A., TOMMIE, J., NOMMSEN-RIVERS, L., & COUCH, S. (2018). Dietary patterns and breast cancer risk: A systematic review. Anticancer Research, 38(6), 3209-3222. https://doi.org/10.21873/anticanres.12586

VEER, P. V., KOK, F. J., BRANTS, H. A., OCKHUIZEN, T., STURMANS, F., & HERMUS, R. J. (1990). Dietary fat and the risk of breast cancer. International Journal of Epidemiology, 19(1), 12-18. https://doi.org/10.1093/ije/19.1.12

Gerber, M., & Cenée, S. (1991). The role of fat, animal protein and some vitamin consumption in breast cancer: A case control study in southern France. International Journal of Cancer, 48(1), 1-9. https://doi.org/10.1002/ijc.2910480102

Franceschi, S., Favero, A., Russo, A., Decarli, A., La Vecchia, C., Ferraroni, M., Decarli, A., Negri, E., La Vecchia, C., Amadori, D., Conti, E., Montella, M., & Giacosa, A. (1996). Intake of macronutrients and risk of breast cancer. The Lancet, 347(9012), 1351-1356. https://doi.org/10.1016/s0140-6736(96)91008-9

Do, M. H., Lee, S. S., Jung, P. J., & Lee, M. H. (2003). Intake of dietary fat and vitamin in relation to breast cancer risk in Korean women: A case-control study. Journal of Korean Medical Science, 18(4), 534. https://doi.org/10.3346/jkms.2003.18.4.534

Al Othaimeen, A., Ezzat, A., Mohamed, G., Muammar, T., & Al Madouj, A. (2004). Dietary fat and breast cancer in Saudi Arabia: A case-control study. Eastern Mediterranean Health Journal, 10(6), 879-886. https://doi.org/10.26719/2004.10.6.879

Romieu, I., Lazcano-Ponce, E., Sanchez-Zamorano, L. M., Willett, W., & Hernandez-Avila, M. (2004). Carbohydrates and the risk of breast cancer among Mexican women. Cancer Epidemiology, Biomarkers & Prevention, 13(8), 1283-1289. https://doi.org/10.1158/1055-9965.1283.13.8

Wang, J., John, E. M., Horn-Ross, P. L., & Ingles, S. A. (2008). Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. Nutrition and Cancer, 60(4), 492-504. https://doi.org/10.1080/01635580801956485

Sulaiman, S., Shahril, M. R., Shaharudin, S. H., Emran, N. A., Muhammad, R., Ismail, F., & Husain, S. N. (2011). Fat intake and its relationship with pre-and postmenopausal breast cancer risk: a case-control study in Malaysia. Asian Pac J Cancer Prev, 12(9), 2167-78.

Zhang, C., Ho, S. C., Lin, F., Chen, Y., Cheng, S., & Fu, J. (2011). Dietary fat intake and risk of breast cancer. European Journal of Cancer Prevention, 20(3), 199-206. https://doi.org/10.1097/cej.0b013e32834572bb

Tayyem, R. F., Mahmoud, R. I., Shareef, M. H., & Marei, L. S. (2019). Nutrient intake patterns and breast cancer risk among Jordanian women: A case-control study. Epidemiology and Health, 41, e2019010. https://doi.org/10.4178/epih.e2019010

Howe, G. R., Friedenreich, C. M., Jain, M., & Miller, A. B. (1991). A cohort study of fat intake and risk of breast cancer. JNCI: Journal of the National Cancer Institute, 83(5), 336-340. https://doi.org/10.1093/jnci/83.5.336

Byrne, C., Rockett, H., & Holmes, M. D. (2002). Dietary fat, fat subtypes, and breast cancer risk: lack of an association among postmenopausal women with no history of benign breast disease. Cancer Epidemiology Biomarkers & Prevention, 11(3), 261-265.

Sieri, S., Chiodini, P., Agnoli, C., Pala, V., Berrino, F., Trichopoulou, A., Benetou, V., Vasilopoulou, E., Sánchez, M.-J., Chirlaque, M.-D., Amiano, P., Quirós, J. R., Ardanaz, E., Buckland, G., Masala, G., Panico, S., Grioni, S., Sacerdote, C., Tumino, R., & Boutron-Ruault, M.-C. (2014). Dietary fat intake and development of specific breast cancer subtypes. Journal of the National Cancer Institute, 106(5), dju068. https://doi.org/10.1093/jnci/dju068

Hadmaș, R. M., Popa, A. D., Cherecheș, R. M., & Benedek, A. (2021). The association between food consumption, inflammatory status, and anthropometric development in children aged 6 to 12 years. Nutrients, 13(6), 2036

Downloads

Published

2025-03-21

How to Cite

Ayub, H., & Ghaffar, F. (2025). Diet, Dyslipidemia and Breast Cancer: Macronutrients Imbalance as Dietary Risk of Breast Cancer among the Pakhtun Women of Khyber Pakhtunkhwa, Pakistan. Indus Journal of Bioscience Research, 3(3), 356-363. https://doi.org/10.70749/ijbr.v3i3.869