Compare the Mean Duration of Active First Stage of Labour Among Primi Gravida Presenting at Term Treated with and Without Hyoscine
DOI:
https://doi.org/10.70749/ijbr.v3i3.897Keywords:
Hyoscine, BMI, Maternal Age, Foetal Weight, Duration of first stageAbstract
Introduction: Diagnosis of labour onset has been described as probably one of the most difficult decisions made by providers of maternity care. The first stage of labour addresses the goal of thinning or effacing the cervix; dilating or opening it for least 10 centimeters in size adequate for passage of the infant from uterus to the vagina. To compare mean duration of active first stage of labour of primigravida presented at term treated with and without hysocine. This study was a randomized controlled trial conducted at the Department of Gynae and Obstetrics, Pakistan Institute of Medical Sciences, Islamabad from July to December 2022. We studied 60 patients (30 per group) who were admitted for labor trial after obtaining their ethical approval. 20 mg IV hyoscine group received 20 mg hyoscine, while control group received none. Active labor duration was monitored. Results: Sixty women consented with an mean age of 25.50±3.45 years. The overall mean duration of the active phase of labour in hyoscine group was 212.62±25.01 minutes and significant (p-value = 0.025) reduction was observed in its duration of the first active stage when compared with conventional group. Maternal age, BMI and foetal weight were used to segregate duration of active stage of labour and there was no significant difference (p value > 0.05). Conclusion: Hyoscine decreases the duration of the active phase of labour in primigravdae without any side effects on the mother or or the neonate. Factors such as age of 35 years and above, higher BMI or neonatal weight had no effect on foetal outcomes.
Downloads
References
Hanley GE, Munro S, Greyson D, Gross MM, Hundley V, Spiby H, et al. Diagnosing onset of labor: A systematic review of definitions in the research literature. BMC pregnancy and childbirth. 2016;16(1):1-11. https://doi.org/10.1186/s12884-016-0857-4
Oladapo OT, Souza JP, Fawole B, Mugerwa K, Perdoná G, Alves D, et al. Progression of the first stage of spontaneous labour: A prospective cohort study in two sub-saharan african countries. PLoS medicine. 2018;15(1):e1002492. https://doi.org/10.1371/journal.pmed.1002492
Ea F. Primigravid labor; a graphicostatistical analysis. Obstetrics and Gynecology. 1955;6(6):567-89. https://doi.org/10.1016/s0029-7844(02)02398-0
Horsager R, Roberts SW, Rogers VL, Santiago-Muñoz PC, Worley KC, Hoffman BL. Williams obstetrics, study guide. 2014.
Nystedt A, Hildingsson I. Diverse definitions of prolonged labour and its consequences with sometimes subsequent inappropriate treatment. BMC pregnancy and childbirth. 2014;14(1):1-11. https://doi.org/10.1186/1471-2393-14-233
Ängeby K, Wilde‐Larsson B, Hildingsson I, Sandin‐Bojö AK. Prevalence of prolonged latent phase and labor outcomes: Review of birth records in a swedish population. Journal of midwifery & women's health. 2018;63(1):33-44. https://doi.org/10.1111/jmwh.12704
Abalos E, Oladapo OT, Chamillard M, Díaz V, Pasquale J, Bonet M, et al. Duration of spontaneous labour in ‘low-risk’women with ‘normal’perinatal outcomes: A systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018;223:123-32. https://doi.org/10.1016/j.ejogrb.2018.02.026
Zhu CP, Jiang F, Wang RQ, Guo XZ, Hou XH, Xu H, et al. Comparison of efficacy and safety of hyoscine butylbromide versus anisodamine for acute gastric or intestinal spasm‐like pain: A randomized, double‐blinded, multicenter phase iii trial. Journal of Digestive Diseases. 2017;18(8):453-60. https://doi.org/10.1111/1751-2980.12504
Orji E. Evaluating progress of labor in nulliparas and multiparas using the modified who partograph. International Journal of Gynecology & Obstetrics. 2008;102(3):249-52. https://doi.org/10.1016/j.ijgo.2008.04.024
Lavender T, Alfirevic Z, Walkinshaw S. Effect of different partogram action lines on birth outcomes: A randomized controlled trial. Obstetrics & Gynecology. 2006;108(2):295-302. https://doi.org/10.1097/01.aog.0000226862.78768.5c
Keane D. Conference on modern management of labour. Held at the royal college of obstetricians and gynaecologists, london. 15th Feburary, 2022.
Ara B, Anwar A, Salam R. Comparison of mean duration of first and second stage of labour in term primigravida with and without phloroglucinol. PJMHS. 2016;10(3):994-7.
Tolentino L, Yigeremu M, Teklu S, Attia S, Weiler M, Frank N, et al. Three-dimensional camera anthropometry to assess risk of cephalopelvic disproportion-related obstructed labour in ethiopia. Interface focus.2019;9(5):20190036. https://doi.org/10.1098/rsfs.2019.0036
Reitter A, Daviss B-A, Bisits A, Schollenberger A, Vogl T, Herrmann E, et al. Does pregnancy and/or shifting positions create more room in a woman’s pelvis? American journal of obstetrics and gynecology. 2014;211(6):662. e1-. e9. https://doi.org/10.1016/j.ajog.2014.06.029
Okumura M, Ishikawa A, Aoyama T, Yamada S, Uwabe C, Imai H, et al. Cartilage formation in the pelvic skeleton during the embryonic and early-fetal period. PLoS One. 2017;12(4):e0173852. https://doi.org/10.1371/journal.pone.0173852
Röthlisberger R, Aurore V, Boemke S, Bangerter H, Bergmann M, Thalmann GN, et al. The anatomy of the male inferior hypogastric plexus: What should we know for nerve sparing surgery. Clinical anatomy. 2018;31(6):788-96. https://doi.org/10.1002/ca.23079
Liselele HB, Boulvain M, Tshibangu KC, Meuris S. Maternal height and external pelvimetry to predict cephalopelvic disproportion in nulliparous african women: A cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 2000;107(8):947-52. https://doi.org/10.1111/j.1471-0528.2000.tb10394.x
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
