Frequency of Kidney Failure in Patient Admitted with Malaria
DOI:
https://doi.org/10.70749/ijbr.v3i3.904Keywords:
Malaria, Acute Kidney Injury, Renal Failure, KDIGO, Public HealthAbstract
Background: Malaria is still a serious public health issue worldwide, especially in tropical and subtropical areas. One serious side effect of malaria that raises morbidity and death is acute kidney damage (AKI). The purpose of this study is to ascertain the prevalence of renal failure in malaria patients who are admitted. Methods: Over the course of six months, a descriptive cross-sectional study was carried out at Bolan Medical College Hospital in Quetta. Included were 177 patients, ages 18 to 70, who had been diagnosed with malaria using the malaria parasite immune chromatographic test (MPICT). Individuals receiving renal replacement treatment, those with chronic kidney disease, and those taking nephrotoxic drugs were not included. Patients were tracked for kidney failure using the KDIGO classification, and baseline clinical and demographic data were documented. SPSS version 25 was used to analyze the data, and p < 0.05 was chosen as the threshold for statistical significance. Results: Kidney failure occurred in 96 (54.2%) of the 177 malaria patients. 48 years old was the median age (IQR: 29.5). 55.9% of the sample was rural, and 55.4% of the sample was male. Plasmodium falciparum (20.3%), Plasmodium vivax (23.2%), Plasmodium ovale (32.2%), and Plasmodium malariae (24.3%) were the species of malaria that were distributed. renal failure did not significantly correlate with gender (p=0.339), residency (p=0.833), diabetes (p=0.058), hypertension (p=0.243), smoking (p=0.477), family history of renal disease (p=0.955), or type of malaria (p=0.821), according to post-stratification analysis. Conclusion: Kidney failure was prevalent (54.2%) among malaria patients, with no significant associations with clinical or demographic factors. Early detection and management strategies are crucial to protecting renal function in malaria cases.
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Afolayan, F. M., Adedoyin, O. T., Abdulkadir, M. B., Ibrahim, O. R., Biliaminu, S. A., Mokuolu, O. A., & Ojuawo, A. (2020). Acute Kidney Injuries in Children with Severe Malaria. Sultan Qaboos University Medical Journal [SQUMJ], 20(4), e312-317. https://doi.org/10.18295/squmj.2020.20.04.006
BARSOUM, R. S. (2000). Malarial Acute Renal Failure. Journal of the American Society of Nephrology, 11(11), 2147–2154. https://doi.org/10.1681/asn.v11112147
Calice-Silva, V., Sacomboio, E., Raimann, J. G., Evans, R., dos Santos Sebastião, C., Tchivango, A. T., Kotanko, P., Levin, N., & Pecoits-Filho, R. (2018). Diagnostic performance of salivary urea nitrogen dipstick to detect and monitor acute kidney disease in patients with malaria. Malaria Journal, 17(1). https://doi.org/10.1186/s12936-018-2627-4
Conroy, A. L., Opoka, R. O., Bangirana, P., Idro, R., Ssenkusu, J. M., Datta, D., Hodges, J. S., Morgan, C., & John, C. C. (2019). Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria. BMC Medicine, 17(1). https://doi.org/10.1186/s12916-019-1332-7
Conroy, A. L., Liles, W. C., & Molyneux, M. E. (2019). Pathophysiology and prognostic indicators of severe malaria. Infectious Disease Clinics of North America, 33(1), 39-60.
Das, B. S. (2018). Renal failure in malaria. Journal of Vector Borne Diseases, 55(2), 85-94.
Dondorp, A. M., Lee, S. J., Faiz, M. A., Mishra, S., Price, R., Tjitra, E., ... & White, N. J. (2008). The relationship between age and the manifestations of and mortality associated with severe malaria. Clinical Infectious Diseases, 47(2), 151-157. https://doi.org/10.1086/589287
George, C. R., Alexander, T., & Mathews, M. S. (2015). Malaria and kidney injury: Clinical implications. Nephrology, 20(2), 79-86.
Greenwood, B., & Mutabingwa, T. (2002). Malaria in 2002. Nature, 415(6872), 670–672. https://doi.org/10.1038/415670a
Gupta, A., Mishra, S., & Kumar, R. (2020). Renal involvement in malaria: A clinical review. Kidney International Reports, 5(3), 229-235. https://doi.org/10.1093/ckj/sfx003
Oshomah-Bello, E. O., Esezobor, C. I., Solarin, A. U., & Njokanma, F. O. (2020). Acute kidney injury in children with severe malaria is common and associated with adverse hospital outcomes. Journal of Tropical Pediatrics, 66(2), 218-225.
Kochar, D. K., Das, A., & Kochar, S. K. (2003). Acute renal failure in falciparum malaria. Journal of the Association of Physicians of India, 51(1), 265-270.
Koopmans, L. C., van Wolfswinkel, M. E., Hesselink, D. A., Hoorn, E. J., Koelewijn, R., van Hellemond, J. J., & van Genderen, P. J. J. (2015). Acute kidney injury in imported Plasmodium falciparum malaria. Malaria Journal, 14(1). https://doi.org/10.1186/s12936-015-1057-9
Lauwerys, B. R., Hus, K. E., & Van Damme, J. (2001). Mechanisms of renal injury in severe malaria. Nephrology Dialysis Transplantation, 16(3), 38-42.
Makris, K., & Spanou, L. (2016). Acute kidney injury: definition, pathophysiology and clinical phenotypes. The clinical biochemist reviews, 37(2), 85. https://pmc.ncbi.nlm.nih.gov/articles/PMC5198510/
Brown, D. D., Solomon, S., Lerner, D., & Del Rio, M. (2020). Malaria and acute kidney injury. Pediatric Nephrology, 35, 603-608. https://doi.org/10.1007/s00467-018-4191-0
Mehta, K. S., Halankar, A. R., Makwana, P. D., Torane, P. P., Satija, P. S., & Shah, V. B. (2001). Severe acute renal failure in malaria. Journal of postgraduate medicine, 47(1), 24-26. https://journals.lww.com/jopm/abstract/2001/47010/severe_acute_renal_failure_in_malaria.5.aspx
Mishra, S. K., & Das, B. S. (2008, July). Malaria and acute kidney injury. In Seminars in Nephrology (Vol. 28, No. 4, pp. 395-408). WB Saunders.
Mishra, S. K., Das, B. S., & Mohanty, S. (2016). Kidney dysfunction in severe malaria. American Journal of Tropical Medicine and Hygiene, 95(6), 1332-1338
Muhamedhussein, M. S., Ghosh, S., Khanbhai, K., Maganga, E., Nagri, Z., & Manji, M. (2019). Prevalence and Factors Associated with Acute Kidney Injury among Malaria Patients in Dar es Salaam: A Cross-Sectional Study. Malaria Research and Treatment, 2019, 1–7. https://doi.org/10.1155/2019/4396108
Nand, N., Aggarwal, H., Sharma, M., & Singh, M. (2001). Systemic manifestations of malaria. J Indian Acad Clin Med, 2(3), 189-194.
Oshomah-Bello, E. O., Esezobor, C. I., Solarin, A. U., & Njokanma, F. O. (2020). Acute kidney injury in children with severe malaria is common and associated with adverse hospital outcomes. Journal of Tropical Pediatrics, 66(2), 218-225.
Plewes, K., Turner, G. D., & Dondorp, A. M. (2018). Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria. Current opinion in infectious diseases, 31(1), 69-77. https://journals.lww.com/co-infectiousdiseases/FullText/2018/02000/Pathophysiology,_clinical_presentation,_and.11.aspx
Prakash, J., Yadav, P., & Kumar, H. (2018). Clinical spectrum of renal dysfunction in malaria. Nephron Clinical Practice, 138(1), 21-28
Report, W. M. (2020). 20 years of global progress and challenges. World Health Organization Geneva.
Romio'r 'E, Brandåo JA. (2017). The outcome of Acute Kidney Injury in patients with severe Malaria. Journal of Clinical Nephrology, 1, 048-054. https://doi.org/10.29328/journal.jcn.1001007
Snow, R. W., Guerra, C. A., Noor, A. M., Myint, H. Y., & Hay, S. I. (2005). The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature, 434(7030), 214–217. https://doi.org/10.1038/nature03342
Thanachartwet, V., Desakorn, V., Sahassananda, D., Kyaw Win, K. K. Y., & Supaporn, T. (2013). Acute renal failure in patients with severe falciparum malaria: using the WHO 2006 and RIFLE criteria. International Journal of Nephrology, 2013(1), 841518. https://doi.org/10.1155/2013/841518
Trampuz, A., Jereb, M., Muzlovic, I., & Prabhu, R. M. (2003). Clinical review: Severe malaria. Critical care, 7, 1-9. https://link.springer.com/article/10.1186/cc2183
Walker, P. G., Whittaker, C., Watson, O. J., Baguelin, M., Winskill, P., Hamlet, A., ... & Ghani, A. C. (2020). The impact of COVID-19 and strategies for mitigation and suppression in low-and middle-income countries. Science, 369(6502), 413-422. https://doi.org/10.1126/science.abc0035
World Health Organization. The world health report 1999; making a difference. World Health Organiza tion, Geneva, Switzerland, 1999.
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